Razi Journal of Medical Sciences

 We tried to decrease the dose of the consumed thiopental during induction of anaesthesia with intramuscular injection of the lidocaine as a premedication by using the lidocaine characteristics in decreasing anaesthesia MAC(minimum alveolar concentration).

  The manner of research performance is as follows: we injected lidocaine 5% (3 mg/kg) or Normal salin (0.06ml/kg) into Gluteus muscle of two hundred adult patients (anaesthesia risk ASA-I, ASA-II) who were Candidate for elective surgical operation (one hundred persons for each group). About 15 minutes after injection, induction of anaesthesia began based on constant protocol.

  After intravenous injection of the Midazolam, the Fenantyl and the Galamin, the Thiopental was injected in boluses at the dose of 0.5 mg/kg in interval of 30 seconds. When the patient can not perform the orders and the eyelash reflex become disordered, the patient intubated with the Succinylcholin. The hemodynamic parameters of the patients (blood pressure and heart rate) are measured before the premedication administration and during intubation.

  Analysing of the obtained results show that the average rate of the consumed Thiopental in the group who received Lidocaine 5% (3mg/kg) as a premedication decrease about 42.5% in compared with the control group during induction of anaesthesia. The stability of the hemodynamic parameters during intubation in the group who received intramuscular Lidocaine is very significant.