Razi Journal of Medical Sciences

Background: Although statins are used for treatment of hyperlipidemia and coronary vascular diseases, recent studies demonstrate their anti-inflammatory and immune system control effects. Target of this study was evaluation of effects of statin consumption on prognosis of patients with sepsis. Material and Method: In this retrospective, case control study, collecting data were collected from patient’s file for 60 patients with sepsis and statin consumption for at least one week and 60 patients with sepsis without previous statin consumption who were admitted to Hazrat Rasoul Akram Hospital. Result: In case group 51% was male with mean age of 57±0.8 years. In control group 49% was male with mean age of 65±0.11 years. In case group 16% and in control group 28% referred to intensive care unit (p value< 0.05) and in case group 15% and in control group 32% died ( p value= 0.03). Mean of total serum cholesterol in case and control group was 170 and 195.2 respectively (p value= 0.03). Conclusion: Severity of sepsis was the same as measured by APACHE П score at the admission time in both groups, but patients with sepsis and statin consumption before admission had better prognosis according to the rate of ICU admission and mortality. It seems that however statin consumption before hospital admission reduces mortality and morbidity of sepsis, statin use during sepsis can not do the same.