Razi Journal of Medical Sciences

Background: Helicobacter pylori infection is one of the most important factors of peptic ulcer and other gastrointestinal disorders. Gastritis caused by H. pylori infection has a high prevalence and about 10 percent of people in their lifetime will suffer from gastritis patients. Some studies have shown an association between Helicobacter pylori and atherosclerosis that may exist. The studies showed that the presence of H. pylori in peptic ulcer gut leads to changes in lipid profile including cholesterol, triglycerides and lipoproteins are HDL-c and LDL-c. The purpose of this study was to evaluate the lipid profile in individuals infected and non-infected with H. pylori in the city of Tabriz is the measurement of total cholesterol, triglycerides, HDL cholesterol and LDL- cholesterol in patients with Helicobacter pylori infection as a standard golden disease progression of atherosclerosis and heart disease rate would be very useful vessel.

Methods: Patients admitted to the Clinic of Imam Reza Hospital Tabriz doctor gastrointestinal endoscopy, gastroscopy was performed. The patients were selected from a blood sample and two biopsies were taken from the pyloric antrum 3 cm remained. H. pylori infected and non -infected patients in both groups were classified. And among them, 58 people as groups or individuals infected with H. pylori infection and 58 healthy individuals who were infected as control group were randomly selected. Total cholesterol, triacylglycerol, HDL- cholesterol and LDL- cholesterol were measured by colorimetric method.

Results: In the group of H. pylori -infected individuals with active peptic ulcer rate, lipid profiles, including total cholesterol, triacylglycerol, LDL and HDL compared with the control group are statistically significant. (In all cases, p=0.0001).

Conclusion: Due to the heavy burden of cardiovascular disease health of the economy and the society make extensive studies conducted during the last decade and the risk factors that increase a person’s risk of heart coronary disease they have identified. H. pylori infection and gastrointestinal diseases abroad, especially vascular disorders (e.g. ischemia heart disease, the phenomenon of early Raynvrd, stroke ischemia) is connected. Many case studies - a witness reported a significant association between H. pylori positive and heart disease - cardiovascular and electrocardiographic changes ischemia that is independent of risk factors and socioeconomic factors cardiac vascular requirements.