Volume 20, Issue 111 (9-2013)                   RJMS 2013, 20(111): 50-57 | Back to browse issues page

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Vosadi E, Ravasi A A, Choobine S, Barzegar H, Borjianfard M. Effect of endurance training and omega-3 supplementation in brain-derived neurotrophic factor (BDNF) in male adult rat hippocampus. RJMS 2013; 20 (111) :50-57
URL: http://rjms.iums.ac.ir/article-1-2718-en.html
Tehran University
Abstract:   (7120 Views)

Background: This study was to examine the effects of endurance training and omega-3 supplementation in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus.


Methods: Twenty eight Wistar rats were divided into four equal groups: control, exercise, diet, and exercise with diet Animals in the exercise group received 8 weeks of endurance training and animals in the diet group were treated with 100/mg/kg/day of omega-3 supplementation via oral gavage for 8weeks. The exercise with diet group received a combination of exercise and also supplementation. Hippocampal BDNF protein was assessed using commercial ELISA methods andthe data were analyzed by one-way ANOVA (p<0.05).


Results: The results showed that BDNF level showed no significance increase in the exercise and diet alone groups. , Moreover, the diet and exercise group revealed a significant increase in BDNF level in comparison with the control and the exercise groups but it was not significant compared with the diet group.


Conclusions: The results of the present study suggest that concurrent administration of omega-3 diet and endurance training has an additive effect in the BDNF level in adult male rat hippocampus.

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Type of Study: Research | Subject: Physiology

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