Razi Journal of Medical Sciences

The effect and outcome of pregnancy in patients with chronic idiopathic glomerulonephritis was studied. The study population consisted of 98 patients. All patients were divided into 8 groups according to presence, absence or coexistence of 3 general risk factors such as hypertension, renal failure and nephrotic syndrome.

The adverse effect of renal disease and risk factors on the outcome of pregnancy was evaluated by increased incidence offetal death, toxemia and premature delivery. The influence of pregnancy on maternal nephropathy was evaluated by unexpected rise of serum creatinine from onset of pregnancy upto six months post delivery.

There was high incidence of fetal death (36%), toxemia (27%), premature delivery (30%) and worsening of maternal nephropathy (28%). Toxemia was more common in hypertensives (P< 0.007) and premature delivery in patients with nephrolic syndrome (P<0.007). Worsening of maternal nephropathy was correlated with renal failure (Por with fetal death rate.