Razi Journal of Medical Sciences

The present article reviews the current position of the etiology of mental disorders in the clinical medicine. To study the contribution of the known factors such as genetic, physical, chemical, and stress factors on the pathogenesis and etiology of mental disorders, most acceptable evidences were gathered. A part of these evidences comes from author's own work. In despite of presence of a rich Iiteratue in psychology, etiology of the psychiatry is unknown. Recent studies in half a century provide some evidence to suggest the neurochemical basis of of the physiology and pathology of the behavioral states. It appears that these neurochemical evidences would provide some suggestions to the hypothesis of mental disorders in the present decade. In this regard, the neuroscience investigations may provide some valuable contribution to the etiology of the mental disorders.