Razi Journal of Medical Sciences

Antiphospholipid syndrome is an autoimmune condition characterized by recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with moderate to high levels of antiphospholipid antibodies. Most of clinical features are results of thrombotic phenomena. The pathophysiologic basis ot this syndrome is still unknown. the diagnosis of this syndrome is made by combination of clinical and laboratory features. Depending on the clinical signs and symptoms, the patients are managed with low-dose aspirin and heparin. In specific conditions, patients are managed with conrticosteroids, immunosuppressive agents or plasmapheresis.