Razi Journal of Medical Sciences

  Introduction: Cutaneous metastasis is a rare presentation of choriocarcinoma and as it is associated with advanced disease, it has poor prognostic sign. To the best of our knowledge about 11 cases of cutaneous metastatic choriocarcinoma were reported in the literature.

  Case Report: A 47-yr –old female complaining of cutaneous lesion with pruritis. She had history of choriocarcinoma following missed abortion. Skin biopsy revealed cytotrophoblast and syncitotrophoblast without chorionic villi. After 3 cycles of chemotherapy, serum βHCG decreased and skin lesion almost disappeared.

  Conclusion: As compared to other organs, skin is an uncommon site for metastatic cancer in the body, as it is usually associated with disseminated disease and grave outcome. However, cutaneous metastasis may be the first harbinger of visceral malignancy of unknown origin and could be an important diagnostic clue. Gynecologists should consider meticulously skin lesions in known cases of disease and even in patients without history of disease, because skin lesion may be the first sign of the disease.