Volume 17, Issue 72 (6-2010)                   RJMS 2010, 17(72): 42-48 | Back to browse issues page

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Fallah S, Ja'farzadeh M, Hedayati M, Haji Hosseini R. Association of M55V Polymorphism of Sumo4 with Type 2 Diabetes. RJMS 2010; 17 (72) :42-48
URL: http://rjms.iums.ac.ir/article-1-1466-en.html
Iran University of Medical Sciences and Health Services
Abstract:   (6435 Views)

    Background & Aim: Sumo4 has recently been found to be mainly expressed in kidney. Single nucleotide polymorphism, which is detected in sumo4, replaces a highly conserved methionine with a valine (M55V) residue. This variant of sumo4 may induce higher nuclear factor–KB (NFKB) activity because NFKB is known to mediate the development of diabetic nephropathy.

Patients and Method: This study involved 50 patients with type 2 diabetes and 50 healthy subjects. The M55V polymorphism of sumo4 was genotyped by PCR and restriction enzyme digestion. The serum glucose concentration was measured by enzymatic method. Students' t-test and Chi-square test were used to analyze the data.

Results: The frequency of sumo4 AA, GA and GG was 20%, 44% and 36% in the case group and 26%, 50% and 24% in the control group respectively.

Conclusion: The results suggest that the sumo4 M55V variant is not associated with type 2 diabetes mellitus susceptibility, suggesting that it may not be involved in the pathogenesis of type 2 diabetes.

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Type of Study: Research | Subject: Biochemistry

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