Razi Journal of Medical Sciences

  Background and Aim: Patients with Chronic Renal Failure (CRF) are at high risk of renal osteodystrophy, and this condition develops at the early stages of chronic renal failure and covers a spectrum of bone changes such as osteoporosis. Hypogonadism is common among men with CRF. Many of the manifestations of hypogonadism such as bone disease, are also frequently seen among dialysis patients. The goal of this study was to determine the levels of testosterone, PTH, LH, BUN, Cr, and Alkaline phosphatase (Alk.p) in men with CRF in two groups with normal and abnormal bone densitometry.

  Patients and Methods: In this cross-sectional study, 63 patients with CRF were evaluated. Bone mineral densitometries (BMD) by DEXA method were requested for all patients. The level of testosterone, PTH, BUN, Cr, Alk.p and LH were compared in two groups with normal and abnormal densitometry. The results were analyzed by Pearson, T and Chi-square tests. A p value of <0.05 was regarded as a significant level.

  Results: Sixty three patients were studied in this research. The average age of the patients was 50.58±13.32 years. We found significant relation between age, level of testosterone and PTH between patients with normal and abnormal BMD(p value<0.05).

  Conclusion: Osteoporosis is an important finding in CRF patients and another study to determine the beneficial results of testosterone replacement therapy is recommended.