Razi Journal of Medical Sciences

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Inotropic requirement of patients under CABG(Coronary Artery Bypass Graft) for CPB(Cardiopulmonary Bypass) weaning depends on multiple factors including: type of heart disease and its severity, co-existing diseases, technical success in surgical operation and the type of anesthetic drugs. Among the above-mentioned factors the effects of anesthetic drugs on inotropic requirement of patients under CABG were studied.The present study was performed as a prospective randomized clinical-trial analysis on 60 patients under CABG in Shahid Rajaii Heart Hospital. Inclusion criteria were: patients aged between 40-60 years, ejection fraction>40% and exclusion criteria were: Patients with underlying and co-existing diseases(exept CAD), pump time more than 2 hours, hypothermia more than 30 degree and cross clamp of aorta more than 45 minutes. Type and dose of premedication drugs, intraoperative opioid and muscle relaxant in two groups were the same and based on the standard of the reference book. The patients were divided into two groups of 30. Induction of anesthesia in the first group was by propofol and in the second group by midazolam. Maintenance of anesthesia in two groups was by infusion of standard doses of anesthetic drugs. All of these patients were studied based on monitoring of hemodynamic changes (heart rate and blood pressure). Results showed that inotropic requirement of patients in group 1(propofol group) was 16.7%, while 30% of patients in group 2(midazolam group) needed inotropic drugs. There was not statistically significant difference between two groups(P>0.05).

Keywords: Key Words: 1) Propofol 2) Midazolam

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