Volume 16 - spring                   RJMS 2009, 16 - spring: 113-119 | Back to browse issues page

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Haghighi A, Hadaegh F, Ghoreifinegadian A R. Evaluation of Bone Mineral Density in Postmenopausal Women With Type 2 Diabetes Mellitus. RJMS 2009; 16 :113-119
URL: http://rjms.iums.ac.ir/article-1-1174-en.html
Abstract:   (8008 Views)

    Background and Aim: Association between type 2 Diabetes mellitus and osteoporosis has been an attractive subject for many researchers, because both of them are very frequent and occure in the same age group. However there are controversial reports on the effect of the type 2 Diabetes mellitus on bone mineral density. Bone mineral density (BMD) of diabetic patients is reported to be equal, more or less than the normal population. The aim of this study was to evaluate the bone mineral density in postmenopausal women with type 2 diabetes mellitus.

Patients and Methods: In this cross-sectional study, 50 diabetic and 50 nondiabetic postmenopausal patients that had referred to Bandar abbas Milad Bone Mineral Densitometry Centre were enrolled. BMD was measured in the lumbar vertebrae (L2-L4) and hip (femoral neck) using DXA method. Exclusion criteria were endocrine or rheumatologic diseases and use of confounding drugs specially steroids. The study population was selected randomly. T-test using Minitab software was used for statistical analysis and P<0.05 was considered as significant.

Results: Age, weight, height and BMI were similar between both groups, but menopausal age was higher in the case group (48.26±4.89 yr vs 45.20±5.75 yr). The mean femoral neck BMD was similar between two groups (0.732 g/cm2 in cases and 0.773 g/cm2 in controls) (P=0.16).

There were no statistically significant differences in BMD of lumber spine in both groups (0.875 g/cm2 vs 0.876 g/cm2, p=0.97). No significant difference was noted in regard to prevalence of osteopenia and osteoporosis.

The mean femoral neck T-score was lower in the case group (-2.18 vs -1.83), but this was not significant (P= 0.16). There were no statistically significant differences in the lumbar spine in this regard as well (-1.40 vs -1.39, p=0.98). The mean Z-score of both sites was also similar in the two groups. The incidence of fracture was similar between two groups. Also there were no significant differences in the T-score and Z-score between patients receiving oral anti-diabetic medication and those receiving insulin.

Conclusion: It seems that type 2 diabetes mellitus is not a risk factor for osteoporosis and does not increase the risk of fracture. So evaluation of BMD is not recommended routinely for prophylaxis of osteoporosis in this patient group.

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Type of Study: Research | Subject: Endocrinology & Metabolism

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