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Background & Aim:
clinical cases especially from hospitalized patients. Recently multiple drug resistant
isolated from clinical cases. Resistances were seen against drugs belonging to different antibiotic families. In this
survey, drug resistance in clinical isolates was studied with special reference to extended spectrum beta
lactamases.
Escherichia coli is one of the most important and prevalent bacteria isolated fromE.coli strains have beenPatients and Method:
for drug resistance by disc diffusion method. The minimal inhibitory concentration (MIC) of isolates resistant to
different antibiotics was determined by E-test. Beta lactamases production was tested with nitrocephin disc and
extended spectrum beta lactamases assays were performed with double disc synergy tests. Finally, Chi-square
and t-tests were used to analyze the data.
A total of 113 E. coli strains isolated from hospitalized patients were initially surveyedResults:
these MDR strains were positive in nitrocephin test, indicating beta lactamases production. Double disc synergy
tests results showed production of extended spectrum beta lactamases in all MDR isolates.
From the total of 113 E.coli isolates tested, 47 (41.5%) showed multi drug resistant trait. All ofConclusion:
Detection of 41.5% MDR trait, especially extended spectrum beta lactamases, in the clinicalE.coli
cephalosporins. It also necessitates conduction of a wider study to determine the extent of MDR
isolates points to the potential dangers posed by the widespread usage of extended spectrumE.colioccurrence at national level.
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