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URL: http://rjms.iums.ac.ir/article-1-2718-en.html
Background: This
study was to examine the effects of endurance training and omega-3
supplementation in brain-derived neurotrophic factor (BDNF) in the male adult
rat hippocampus.
Methods: Twenty eight
Wistar rats were divided into four equal groups: control, exercise, diet, and
exercise with diet Animals in the exercise group received 8 weeks of endurance
training and animals in the diet group were treated with 100/mg/kg/day of
omega-3 supplementation via oral gavage for 8weeks. The exercise with diet
group received a combination of exercise and also supplementation. Hippocampal
BDNF protein was assessed using commercial ELISA methods andthe data were
analyzed by one-way ANOVA (p<0.05).
Results: The
results showed that BDNF level showed no significance increase in the exercise
and diet alone groups. , Moreover, the diet and exercise group revealed a
significant increase in BDNF level in comparison with the control and the
exercise groups but it was not significant compared with the diet group.
Conclusions: The results of
the present study suggest that concurrent administration of omega-3 diet and
endurance training has an additive effect in the BDNF level in adult male rat
hippocampus.
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