Research code: مقاله مستخرج از رساله دکتری است
Ethics code: IR.KMU.REC.1396.1562
Clinical trials code: مقاله مستخرج از رساله دکتری است

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Islamic Azad University , Arshadi.sajad@yahoo.com
Abstract:   (96 Views)
Background: The aim of the present study was to investigate the effect of regular aerobic exercise and vitamin D supplementation on hepatic apoptosis in rats exposed to oxygenated water (H2O2). Methods:For this purpose, 60 adult male Wistar rats weighed 220±20 g were randomly divided into ten groups. Then, the animals were exposed to oxidative stress (intraperitoneal injection of H2O2 3 times a week), vitamin D3 (intraperitoneal injection daily) and daily treadmill exercise for 8 weeks (duration of training sessions 30 to 60 min, at speeds of 8 to 20 m/min).The rats were sacrificed 24 hours after the last training session and liver tissue was extracted and Caspase-8 protein concentration was measured by ELISA method.One-way ANOVA was used to compare the between groups differences.Results: The results showed that Caspase-8 protein levels were higher in the H, 2H, HD and 2HD groups compared to the control group (p<0.01).Also, HE and HDE groups as well as 2HE and 2HDE groups showed lower levels of Caspase-8 protein in liver tissue compared to H and 2H groups, respectively (p <0.001).Conclusion: the results showed that exposure of rats to H2O2 induces apoptosis in liver tissue. regular treadmill exercise was able to attenuate this effect to a large extent, but vitamin D3 supplementation did not.
     
Type of Study: Research | Subject: Exercise Physiology

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