Volume 26, Issue 1 (4-2019)                   RJMS 2019, 26(1): 50-58 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jazini M, Roghanian R, Zarkesh Esfahani H, Shaygannejad V, Mirmosayyeb O. Evaluation of the possible relation between neuromyelitis optica and mumps infection in Isfahan, Iran. RJMS 2019; 26 (1) :50-58
URL: http://rjms.iums.ac.ir/article-1-5311-en.html
Esfahan University, Esfahan, Iran , r.roghanian@sci.ui.ac.ir
Abstract:   (4415 Views)
Background: Neuromyelitis Optica (NMO) is an autoimmune inflammation of central nervous system in which autoantibodies are released against AQP-4 (astrocytic water channels) and diagnosed with transverse myelitis and optic neuritis. Viral infections could be pro-inflammatory agents in body organs including nervous system. Due to such inflammatory reactions, autoantibodies would cross the blood brain barrier. Therefore, recognizing the viral agents may help us to prevent and treat NMO. The aim of the present study was to assess the possible association between NMO and mumps virus.
Methods: This observational study was conducted on 25 NMO patients, 30 Multiple Sclerosis (MS) patients and 30 healthy individuals. Serum IgG and IgM antibodies against mumps, was detected by ELISA using Euroimmun kit (manufactured by Germany). Statistical analysis was performed by SPSS software.  
Results: IgG titer was positive in 76, 53 and 46% of NMO patients, MS patients and healthy individuals, respectively. Statistical analysis demonstrated that level of IgG was significantly higher among groups, However, IgM levels showed no significant difference.
Conclusion: Significant increase of IgG titer against mumps virus in NMO patients and low level of IgM may indicate that an old infection of mumps in NMO patients’ life could have a possible role in the pathogenesis of NMO.
 
 
 
Full-Text [PDF 755 kb]   (1094 Downloads)    
Type of Study: Research | Subject: Immunology

References
2. 1. Mitsdoerffer M, Kuchroo V, Korn T. Immunology of neuromyelitis optica: a T cell–B cell collaboration. Ann N Y Acad Sci; 2013.1283(1):57-66.
3. 2. Chiu C, Xian W, Moss A. Flying in silence: Echolocating bats cease vocalizing to avoid sonar jamming. 2008;105(35): 13116-21.
4. 3. Melamed ‌E, Levy M, Waters PJ, Sato DK, Bennett JL, Jhon GR, et al. Neurol Neuroimmunol Neuroinflamm; 2015.2(4):e134.
5. 4. Weinshenker BG, Wingerchuk DM, Pittok SJ, Lucchinetti CF, Lennon VA. NMO-IgG: a specific biomarker for neuromyelitis optica. Dis Markers; 2006.22(4):197-206.
6. 5. Jarius S, Wildemann B. The history of neuromyelitis optica. J Neuroinflammation; 2013.10(1):8.
7. 6. Aboul-Enein F, Rauschka H, Kornek B, Stadelmann C, Stefferl A, Bruck W, et al. Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. J Neuropathol Experim Neurol; 2003.62(1):25-33.
8. 7. Kalluri SR, Illes Z, Srivastava R, Cree B, Menge T, Bennett JL, et al, editprs. Quantification and functional characterization of antibodies to native aquaporin 4 in neuromyelitis optica. Arch Neurol; 2010;67(10):1201-1208.
9. 8. Moore F Human herpes virus 6 and multiple sclerosis, Wolfson C. Acta Neurol Scand; 2002.106(2):63-83.
10. 9. Koga M, Takahashi T, Kawai M, Fujihara K, Kanda T. A serological analysis of viral and bacterial infections associated with neuromyelitis optica. J Neurol Sci; 2011.300(1):19-22.
11. 10. Mori M, Hosoya M, Hiwasa T, Hayakawa S, Uzawa A, Kuwabara S. Detection of mumps virus RNA in cerebrospinal fluid of patients with neuromyelitis optica. Neurol Sci; 2011.32(5):795-799.
12. 11. Zamvil SS, Slavin AJ. Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder? Neurol Neuroimmunol Neuroinflamm; 2015.2:e62.
13. 12. Hayakawa S, Mori M, Okuta A, Kamegawa A, Fujiyoshi Y, Yoshiyama Y, et al. Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. J Neuroimmunol; 2008.196(1):181-187.
14. 13. Bansal R, Kalita J, Msra U, Kishore J. Myelitis: a rare presentation of mumps. Pediatr Neurosurg; 1998.28(4):204-206.
15. 14. Kashipazha D, Mohammadianinejad SE, Majdinasab N, Azizi M, Jafari M. A descriptive study prevalence, clinical features and other findings of neuromyelitis optica and neuromyelitis optica spectrum disorder in Khuzestan Province, Iran. Iran J Neuro; 2015.14:204.
16. 15. Etemadifar M, Dashti M, Vosoughi R, Abtahi SH, Ramagopalan SV, Nasr Z. An epidemiological study of neuromyelitis optica in Isfahan. Mult Scler; 2014.20:1920-22.
17. 16. Sahraian M, Moinfar Z, Khorramnia S, Mohammad Ebrahim M. Relapsing neuromyelitis optica: demographic and clinical features in Iranian patients. Eur J Neurol; 2010.17:79-49.
18. 17. Mealy MA, Wingerchuk DM, Greenberg BM, Levy M. Epidemiology of neuromyelitis optica in the United States: a multicenter analysis. Arch Neurol; 2012.69:1176-80.
19. 18. Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol; 2010.19:7-35.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb