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Alborze university of medical science,Karaj,Iran , aliehsanheidari@gmail.com
Abstract:   (65 Views)
Background: Malaria is one of the most important tropical diseases that is prevalent in some regions of Iran and world. The malaria agent is resistant to most chemical drugs.  These drugs also have several side effects, so the use of various medicine plants, especially the different species of Artemisia for the active ingeredient, is important significantly. therefore, the aim of this study was to evaluate the antimalarial effects by alcoholic extract of Artemisia fragrance herbal in compared with chloroquine treatment in labratory albino mice exposed to Plasmodium berghei.
 
Methods: In this experimental study, using of  peters method, twenty-five  mice were divided into five groups(n=25 mice/group) in separate cages that four groups were infected with plasmodium berghei., Two groups were treated with(25 and 75 mg/kg) different concentrations by alcoholic extract of Artemisia fragrance and one group treated with chloroquine . The fourth group was assigned as a control group without any drugs. All the mice were administered intraperitoneally(IP) once a day for four days. The percentage of parasitemia on 5 and 8 days in compared with control group was evaluated. The fifth group was tested for evaluation of the extract toxicity on mice without parasite injection. Data were analysed using SPSS software and T-test and the most effective concentration was found between several concentrations.
Results: in the treated group with the concentration 25mg/kg of mice, the parasitemia in the fifth and eighth days was 5.1% and 11.7%, respectively. There was a significant difference in the parasitism between this first group and placebo group during the mentioned days (P<0/001). In the treated group with the concentration of 75mg/kg of mice, the parasitmia in the fifth and eighth days was 3.3% and 5.6%, respectively.There was a significant difference in the parasitism between this group and placebo group during the mentioned days (P<0/001). In compared with two groups receiving (25 and 75mg/kg) concentrations of extract, were showed a significant difference in parasitemia reduction on the 5 day (P<0/005). Mice Survival rate in treated group with chloroquine and concentration 75 mg/kg of extract follow up for a month, showed that  no statistically significant difference and in compared with other groups, this increase was statistically significant(p<0/05).
Conclusion: this study showed that alcoholic extract of Artemisia fragrance had a significant effect in 75mg/kg concentration against the plasmodium bergei parasite.
     
Type of Study: Research | Subject: parasitology

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