Dr Maryam Aliannezhadi, Engineer Masoomeh Faez,
Volume 24, Issue 162 (12-2017)
Abstract
Background and Purpose:
Cancer is a major public health problem worldwide and is one of the most leading causes of death in the world. The number of cancer survivors is increasing because of early detection, new treatment methods and growth of the population. Also, the extensive researches continue to achieve the best practical treatment. Hyperthermia by High-Intensity Focused Ultrasound (HIFU) is one of the newest and the most practical non-invasive techniques in cancer treatment so, using HIFU in the treatment of solid cancerous tumors and its efficiency is evaluated in this paper.
Material and methods
In the method, the temperature is increased in the tissue and tumor by using HIFU absorption and maintains temperature. By maintaining temperature the condition is created so that Irreversible changes are occurred in the cells and it leads to cell death. So in this approach, heat is used to induce the tumor ablation without thermal damage to normal tissue surroundings. This technique can reduce significantly the side effects. It has the potential to cause selective necrosis by heating or cavitation without entering an electrode into the tumor. Also, using HIFU is considered to treat solid tumors, including prostate, liver, breast, kidney, bone and pancreas cancerous tumors. According the results, this approach could be an appropriate alternative technique to surgical excision. In addition, it relieves pain in the advanced cancer. Patients accept this method more easily, psychologically and cosmetically. Finally, HIFU ablation can induce immune response, and suppression of the tumor activity. Therefore, High-intensity focused ultrasound ablation may play a key role in future clinical cancer treatment.
Tayyeb Pourfallah,
Volume 25, Issue 8 (11-2018)
Abstract
One major strategy, technology-driven improvement of treatment conformity in cancer treatment, including advanced image guidance, advanced charged particle therapy (CPT), and application of nanoparticles in hyperthermia, will enable further widening of the therapeutic window of cancer treatment in the era of precision medicine.
The state of the art treatment in photon-therapy is advanced 3D conformal treatment, including the use of intensity-modulated radiation therapy (IMRT) techniques with image guidance (image-guided radiation therapy; IGRT) and stereotactic radiotherapy.
Radiotherapy with high-energy charged particles has become an attractive therapeutic option for patients with several tumor types because of their unique depth dose characteristics, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may allow escalation of tumor doses, improving local control and survival while at the same time reducing toxicity and improving quality of life.
By introducing nanotechnology and biomedical application of nanoparticles and redefining the biological rationale of hyperthermia along with the availability of better hard and software, hyperthermia also permits safer and more effective treatment and holds great promise for combating cancers.
This review, describes technology driven improvements in photon-therapy, CPT and nanohyperthermia including merits/drawbacks and the action domains of each method in cancer treatment.
