Razi Journal of Medical Sciences

  Background: Mean platelet volume (MPV) is associated with platelet reactivity. Large platelets contain more thrombogenic factors than small ones. Previous studies have shown platelet reactivity in patients with pulmonary thromboembolism (PTE).The aim of this study was to investigate the mean platelet volume (MPV) and platelet count in patients with PTE and healthy control subjects.

  Methods : In This study, 210 patients with PTE were retrospectively evaluated. The diagnosis of PTE was made clinically and was confirmed with CT angiography. 210 healthy subjects matched for age, gender and body mass index (BMI) served as control group. We recorded the main demographic, clinical and laboratory data of groups. MPV values and platelet counts were measured at the first day of admission.

  Results: Mean age between PTE patient and control group was 52.6 ± 19.7 vs. 49.43 ± 20.68 years respectively (p=0.109) .MPV was significantly higher among patients with PTE in comparison with control group (10.57 ± 1.08 vs. 9.80 ± 0.86 fL respectively p= 0.000). Platelet count was not significantly different in PTE patients and control group (231.76 ± 92.22 vs. 243.76 ± 67.32 × 10 ⁹ /L, respectively p= 0.129).

  Conclusion : MPV is a simple and easy test and it can be used as an activity marker of platelet function in PTE. It also shows the platelet production rate and stimulation. We have shown that MPV was increased in patients with PTE. Platelet count was not different between PTE patients and control group.

Background: Misdiagnosis and treatment of Deep Vein Thrombosis (DVT) and Pulmonary Thromboembolism (PTE) usually cause some problems and also lengthen the hospitalization period and treatment costs. Prophylaxis often reduces the risk of DVT and following PTE, therefore in this study we aimed to determine the frequency of using Prophylaxis to prevent DVTs in Rasoul Akram hospital in Tehran, Iran.

Methods: In this Retrospective descriptive study, 202 participants were chosen from the patients admitted for surgery in the surgery unites and randomly stratified and classified. Information was extracted for these participants, based on variables and the objectives of this study and after that the frequency of using prophylaxis to prevent DVT was calculated by using descriptive analysis tool.

Results: Our study consisted of 105 male (%52) and 97 female (%48) patients in which 62(%30.7) were from surgery unite, 52(%25.7) orthopedic , 36( %17.8) Gynecology, 33(%16.3) neurosurgery and 19(%9.4) urology. 114(%56.43) of participants received prophylaxis versus 88 (%43.56) the patients did not receive prophylaxis. 13 in high risk groups, 10 in the moderate risk group and 91 were in low-risk group.

Conclusion: In our study, the correct usage of prophylaxis was in %24.3 of incidents, which was consistent with previous studies. In older populations who are subject to more risks in treatment, it is very important to employ more precise prophylaxis treatments. In this study only %14 of participants were from high risk group. Regarding the serious need for prophylaxis to prevent DVT in this particular population, the expansion of our studies toward those populations in higher risks is absolutely suggested.