Showing 9 results for Magnesium
Hadi Samaee,
Volume 6, Issue 1 (6-1999)
Abstract
The meconium plug syndrom is a benign form of colon obstruction in the neonate caused by a firm white plug of mucus. These babies usually present with abdominal distention. Abdominal X ray film reveals distended loops of bowels. Barium enema shows a long radiolucency within the desending colon. The plug is passed after the barium enema or a saline rectal irrigation.
Although meconium plug syndrom is found in otherwise completely normal infants because it can be difficult to differntiate from hirschprung disease and to rule out cystic fibrosis and hypothyroidism, a rectal biopsy, sweat test and thyroid function tests may be necessary to obtain in infants with meconium plug syndrom. This syndrom is occasionally seen in neonates due to use of magnesium sulfate after treatment for eclampsia.
In this article we are reporting a rare case of meconium plug syndrom due to hypermagnesemia used for treatment of eclampsia.
Ladan Haghighi,
Volume 6, Issue 3 (12-1999)
Abstract
In this study a comparison was made between the efficacy and side effects of nifedipine and magnesium sulfate in inhibition of preterm labor. 74 cases in preterm labor were randomized to either oral nifedipine (n = 34) or intravenous magnesium sulfate (n = 40). All cases were primigravid with singleton pregnancies and gestational ages of 23-36 weeks. Both groups were similar in terms of age, gestational age and cervical dilatation. There was no significant difference between effectiveness of magnesium sulfate (70%) and nifedipine (76.5%) in arresting labor and delaying delivery more than 48 hours. Also the difference between maternal complications was not significant in these groups. But, the time needed to stop preterm labor was shorter with nifedipine (2.98 ± 3.02 hours) than magnesium sulfate (4.8 ± 4.23 hours) (P = 0.04). So, as the administration of nifedipine is easier and its effect appears faster than magnesium sulfate and the difference between efficacy . |
and side effects of these drugs is not significant, it can be concluded that nifedipine is an appropriate alternative to the magnesium sulfate in meneqement of preterm labor. |
Sh Nasernezhad, V Hassani, M Taghinejad, M.r Mohaghegh Dolatabadi, M Razi, L Hosseini Gohari,
Volume 9, Issue 31 (3-2003)
Abstract
In a randomized double blind clinical trial study with two parallel group, we assessed the analgesic effect of perioperative magnesium sulfate administration and its effect on serum norepinephrine 24h after diagnostic artheroscopic surgery in 50 ASA physical status I & II patients under general anesthesia with total intravenous anesthesia (TIVA) technique. The patients received either magnesium sulfate 50 mg/kg preoperatively and 8 mg/kg/h intraoperatively or the same volume of isotonic solution intravenously. Anesthesia was performed with midazolam (0.2mg/kg for induction, 1μg/kg /min for maintenance) and fentanyl (3 μg/kg) for induction, and atracurium (0.5 mg/kg) for intubation. Intraoperative pain was defined as an increase of systolic blood preasure and heart rate of more than 20% from baseline values (systolic blood preasure and heart rate 5 min after intubation) and was treated with bolus fentanyl (1-2μg/kg). Postoperative analgesia was achieved with fentanyl (0.5 μg/kg) and evaluated using the pain visual analog scale for 4h (0, 30, 60, 90, 120, 240min). Also 24h after surgery a blood sample was taken from the patients in order to measure serum norepinephrine. During intra-and postoperative period, patients in case group required significantly less fentanyl than those in control group (control group 75+40.18μg versus case group 41+32.97μg, p=0.002 and control group 153+65.87 μg versus case group 72+52.69 μg p=0.001 for intra and postoperative period, respectively) but there is no significant difference in serum level of norepinephrine between two groups. (case group 0.318+0.109 versus control group 0.312+0.182, p=0.9). We concluded that magnesium sulfate, although, reduce the intraoperative and postoperative pain and fentanyl requirement, but there is no significance difference in serum norepinephrine level 24h after surgery between two groups. So reduction of pain dose not have any effect on serum norepinephrine concentration.
F Almasganj, F Saneifard, H Shokoohi,
Volume 10, Issue 34 (9-2003)
Abstract
Urge incontinence(UI) is the most common clinical types of urinary incontinence in elderly women. In neurolohically normal patients, detrusor instability(DI) is a common cause of UI. Treatment of this condition is primarily pharmacologic(Anticholinergics, Calcium antagonists), with surgical options being reserved for selected patients. In an experimental double- blined placebo- controlled study the symptoms, micturation variables and cystometry results were compared before and after of treatment. Twelve of 30 (40%) in drug group(D) considered themselves improved and 60% unchanged. Of the 30 women in the placebo group(P) only 16.7% considered themselves improved, a statistically significant response in favor of the drug group(p=0.001). Micturation variables were statistically changed in favor of magnesium hydroxide. In drug group, number of nocturnal episodes changed form 1.8 to 1.3 times per daytime, frequency changed from 12.4 to 10.4 and daytime incontinence changed from 3.2 to 2.3 times. In placebo group these changes is not significant(P=0.096). Among drug and placebo groups changes in detrusor pressure rise and first sensation volume before and after treatment is statistically significant but other parameters showed no statisically significant differences in any category. In conclusion magnesium hydroxide was more effective than placebo but note that this improvement was mush more apparent on subjective assesment than on objective evaluation of cystometric and micturation data.
Sh Naser Nejad, V Hassani, H Farahini, Hosseini Gohari, Mohaghegh Dolat Abadi, A.r Javanshir,
Volume 10, Issue 36 (12-2003)
Abstract
Reducing the stress neuroendocrine and acute phase responses to surgical trauma during anesthesia has always attracted the attention of anesthesiologists. In order to achieve this goal, different drugs and methods have been used for prevention. The goal of this study was to evaluate the magnesium sulfate effects on serum level changes of stress hormone, neuroendocrine and acute phase reactant and then compare these effects with spinal anesthesia induced changes. In this study, 60 patients who were candidates for diagnostic knee arthroscopic surgery were randomly allocated to three groups(Group 1, 2 and 3). In the first group the patients received total intravenous anesthesia(TIVA) with midazolam, fentanyl and atracurium plus magnesium sulfate. In group 2 the patients received total intravenous anesthesia in the same way but did not receive magnesium sulfate and in the third group only spinal anesthesia was performed. Pain was evaluated with visual analog scale(VAS) in the three groups and fentanyl intravenous was administered during 24 hours after the surgery in the condition that VAS was more than 3. Acute phase response indicators, stress responses and neuroendocrine (Norepinephrine) hormones were measured 24 hours after the surgery. Results obtained from ANOVA, T-test, X2 and SPSS software were analysed with significant Pvalue of 0.05 and in contrast to previously preformed studies the level of norepinephrine and some other hormones showed no significant difference. Comparisons made between the three groups using analysis of variance(ANOVA) showed significant differences in T3 (P=0.000), T4 (P=0.016), GH(P=0.045), BS(P=0.043), WBC(P=0.004) and CRP+(P=0.024). The results of this study have shown that magnesium sulfate has no significant effect and spinal analgesia has relative effect on the neuroendocrine, acute phase and stress hormone responses respectively.
Mahmood Imani, Mahmood Rezaee-Pour, Mehdi Mohamdi, Mehdi Shiri, Maysam Noroozifar, Nasrin Mahmodi,
Volume 19, Issue 100 (10-2012)
Abstract
Background : Binding indirect bilirubin to neuronal membranes receptors such as N-methyl-D-aspartate (NMDA) causes permanent injuries. Magnesium (Mg) ion is proposed to be one of the most important antagonistic regulators of this receptor. We studied relationship between serum levels of total magnesium and total bilirubin before and after phototherapy in term neonates to find new therapeutic and management techniques and the best time for discharge.
Methods: In this semi-experimental, we evaluated icteric neonates whom admitted to Zahedan Imam Ali hospital from March 2009 to March2010. Neonates with symptoms in favor of sepsis, hemolysis and with administration of magnesium sulfate in their mother were not included in this study. The collected data were analyzed by paired sample t-test, and Analysis of Variance via SPSS software.
Results: 90 patients with icterus were studied. Hyperbillirubinemia frequencies before phototherapy included Mild (14-16mg/dl) 28.8%, Moderate (16-18) 33.3% and, Severe (≥18 ( 37.7% Hyperbillirubinemia. Means of billirubin levels were 18.38mg/dl before and 12.99 mg/dl after phototherapy (p<0.0001 T= 19.44). Mg levels were also 2.669 before phototherapy, and 2.03 afterwards (p< 0.001 T= 5 . 13). Levels of magnesium in neonates with severe hyperbilirubinemia were higher than mild hyperbilirubinemia group (p= 0.03) before phototherapy. ANOVA- test results showed significant differences between total magnesium levels just in severe hyperbilirubinemia and bilirubin below 14 groups after phototherapy (p= 0.016) respectively. There was a correlation between total magnesium and total bilirubin levels before (r= 0.315, p= 0.001) and after phototherapy (r= 0.314 p = 0.004).
Conclusion: It is concluded that phototherapy can decline total magnesium and total bilirubin serum levels in the same direction.
Ladan Afshar Khas, Azita Tavasoli, Shirin Shamel,
Volume 21, Issue 121 (7-2014)
Abstract
Background : Febrile convulsion (FC) is one of the most common seizure disorders in childhood period. Some trace elements such as magnesium may contribute in pathogenesis of FC. The aim of our study was to compare serum level of magnesium in children with FC and febrile patients without seizure.
Methods: This prospective, case – control study included two groups of patients with 6-60 month of age with FC and fever without seizure respectively .Forty – seven cases were enrolled in each groups. The serum levels of magnesium were measured by spectrophotometery. Data were analyzed by T-test and Chi-square.
Results: Mean age of cases with FC and febrile patients without seizure were 26.3±18.99 and 23.28±19.11 months respectively .There were 24 male and 23 female in FC group , 26 male and 21 female in another group. The mean age and sex distribution were similar in these two groups.
Mean levels of magnesium were 1.96±0.28 mg/dl and 2.15±0.24mg/dl in cases with FC and febrile patients without seizure respectively and there was a significant difference (p= 0.001). The magnesium level was significantly lower in FC patients.
Conclusion: In our study Serum level of magnesium was lower in FC group in comparison with patients with fever but without seizure. .Magnesium may play an important role in producing seizure in febrile children. In future the use of supplemental magnesium may prevent febrile seizure.
Ali Heidarianpour, Samira Nazarivosogh,
Volume 23, Issue 149 (11-2016)
Abstract
Background: Many evidences have shown that aerobic exercise can alter the function and release certain neurotransmitters such as opioids in the brain. In this research, the effect of endurance exercise (running on a treadmill for six weeks) and oral magnesium sulphate on pain threshold of addicted rats following withdrawal syndrome was investigated.
Methods: In this study male wistar rats weighting 250±20g were used. Morphine sulphate 0.4 grams per liter was added to the animal’s water and after 21 days they were addicted to morphine. Endurance exercise training was used to train animals for six weeks. At the end of the second, fourth and sixth weeks of exercise protocol, naloxone hydrochloride were injected at a rate of 3 mg/kg. Magnesium sulphate 10 grams/liter was dissolved for six weeks in drinking water of animals that were taking magnesium sulphate. A tail-flick apparatus were used to evaluate the effect of exercise and magnesium sulphate on pain threshold.
Results: Results showed that treadmill running exercise (p<0.05) and intake of magnesium (p<0.01) caused a significant increase in pain threshold in addicted rats at withdrawal period. Also, the simultaneous effect of running exercise and intake of magnesium sulphate on pain threshold was greater than any component solely.
Conclusion: According to the findings of this study, it seems that the effect of exercise can be potentiated with magnesium sulphate and may be helpful to ease the pain at withdrawal period.
Tahere Sarboozi Hossain Abadi, Hamid Beyzaei, Seyed-Hadi Hashmi, Behzad Ghasemi, Amir Smaily,
Volume 26, Issue 7 (10-2019)
Abstract
Background: Enterobacter aerogenes (E. aerogenes) is one of the causes of hospital-acquired infections, which its standard strains quickly become resistant to the antibiotics. The discovery of new inhibitory agents against this pathogen is constantly expanding. In this study, the inhibitory effects of several synthetic chemical compounds including magnesium oxide nanoparticles and thiazole, imidazolidine and tetrahydropyrimidine derivatives and natural compounds including nisin and poly-L-lysine were evaluated against E. aerogenes.
Methods: The project is an experimental study. Solutions of all compounds with a specific initial concentration were prepared in 10% DMSO. Antibiogram tests were performed by disc diffusion and broth micro dilution methods according to CLSI guidelines.
Results: Thiazole and tetrahydropyrimidine derivatives, magnesium oxide nanoparticles, nisin and poly-L-lysine had no inhibitory effects on E. aerogenes. Only, imidazolidines 10a and 10c were effective against E. aerogenes with Inhibition Zone Diameter (IZD) = 6.12 and 11.52 mm, Minimum Inhibitory Concentration (MIC) = 1024 and 256 μg/ml, and Minimum Bactericidal Concentration (MBC) = 2048 and 512 μg/ml, respectively.
Conclusion: The inhibitory effects of imidazolidines10a and 10c were proved on the standard strains of E. aerogenes. Design and synthesis of new and more effective derivatives having imidazolidine skeletons can be considered in future studies.
