Mostafa Safari, Akram Gholamzadeh, Akbar Asadi, Mohammad Mahjoor,
Volume 27, Issue 2 (4-2020)
Abstract
Multiple Sclerosis (MS) is one of the most common diseases of the immune system affecting the central nervous system. The etiology of the disease is unclear, but activation of immune mechanisms against inflammation itself seems to play a role in the disease. Ginseng is one of the most popular herbal remedies in traditional medicine that can have soothing properties, promote health and prevent diseases. This study will review several reports on the effects of ginseng on MS. Ginseng is derived from a Greek word (pana kos) which means to cure all diseases. The possible route of positive effects of ginseng can be through anti-inflammatory, antioxidant, hemostatic and biological metabolism. Ginseng's therapeutic properties have been found in a variety of diseases, such as cardiovascular, neurological, cognitive, and autoimmune diseases. Ginseng is suggested to have preventive and therapeutic properties in MS. In this study we reviewed data by using Google Scholar, Science Direct and Pubmed as well as by searching key words: MS, Ginseng, Inflammatory factors and Oxidative stress, from 1990 to 2018.
The modulating effects of ginseng on Th1 and TH17 cells activity and enhancing Treg activity as well as anti-inflammatory and antioxidant effects of ginseng can be used in the treatment of MS as immunological strategies.
Sepideh Tashakori, Davood Khorshidi,
Volume 27, Issue 3 (5-2020)
Abstract
Background: The intense and exhaustive exercise causes oxidative stress and cell damage. The purpose of this study was to investigate the effect of short-term ginseng supplementation on biochemical markers of cell damage following intense anaerobic exercise.
Methods: In this semi-experimental study, 20 active girl students with the mean age of 22.85±3.7 years were randomly divided into experimental (n=10) and control (n=10) groups. Subjects of the experimental and control groups respectively received two capsules of ginseng (1036 mg) or placebo daily for seven days. All subjects participated in an intense anaerobic exercise test (Rast) after supplementation period. Lactate, lactate dehydrogenase and aspartate aminotransferase levels were measured in three phases; baseline, after supplementation and immediately after anaerobic exercise test. Data were analyzed by repeated measure ANOVA.
Results: Lactate, lactate dehydrogenase and aspartate aminotransferase levels significantly increased after the exercise test in the two groups (p˂0.05). However, there were no significant differences in levels of Lactate p=0.35), lactate dehydrogenase (p=0.14) and aspartate aminotransferase (p=0.47) between experimental and control groups following exercise test.
Conclusion: Based on the findings of this study, it can be concluded that short-term ginseng supplementation has no effect on biochemical markers of cell damage following intense anaerobic exercise.
