Search published articles


Showing 5 results for Shafa
Methotrexate in the Treatment of Juvenile Rheumatoid Arthritis
Nahid Shafaei,
Volume 5, Issue 1 (Autumn 1998 1998)
Abstract

Juvenile Chronic Arthritis (JCA) and Juvenile Rheumatoid Arthritis (JRA) are a group of heterogenous idiopathic arthritis with an unclear pathogenesis, most probably, autoimmune phenomenon.

The goals of chemotherapy in JRA are to suppress chronic synovitis, to control the systemic effects of the disease on growth and developement of the patients and, ideally, to make young patients lead a normal life. MTX. has proved to be the most effective drug in this therapeutic measures of these patients, but the side effects of the drug are potentially serious and the most important cause for concern the tratment of chi/ren and young adults.

Although the mechanism of action of MTX is not fully known, it is said to modify the cytokine synthesis, and with the low dose, increase the adenosine release.

In this article we have reviewed the effect of MTX on JCA and JRA during the past 10 years. The results show wide use of MTX. on pediatr c rheumatology patients.

For the best results the drug should be used within two years after the diagnosis. The therapy should conform to the protocol of the Pediatric Rhematology Collaborative Study Group (PRCSG). The suggested dose is 10 mg/m2/ week orally. Although the side effects are potentially serious, the use of this drug, under certain considerations is acceptable. Folic acid may decrease some of the side effects. Dehydration, for any reason, and the use of cotrimoxazole should be avoided.

When the disease comes under control, the drug can be prescribed every other week.


Clinicoepidemiologic Study of Multiple Sclerosis in Patients Who Admited in Shafa Hospital in Kerman
Mohammad Ali Shafa, Hossein Ali Ebrahimi, Amir Hossein Salari,
Volume 5, Issue 1 (Winter 1999 1999)
Abstract

A clinicoepidemiologic study has been done on patients with muliple sclerosis from 1991-1994 in Shafa Hospital in Kerman.

Diagnostic criteria were based on clinical findings and brain and spine MRI scanning. The patients were followed for 1-5 years. 60 patients were diagnosed of whom 30 were from Kerman city. Female to male ratio is 1.14/1. The patients had no family history for multiple sclerosis. The onset of disease was mostly in the third decade of life.

The most common clinical signs and symptoms were in this order: dizziness (81.7%), fatigability (75%), lower extremities spastic paresia (68.7%), sphincteric disorders (55%), ataxia (48.3%), visual loss (45%), Lhermitte sign (40%), diplopia (36.6%), moderate or sever psychiatric disorders(31. 7%), dysarticulation (11.7%) and seizure (5%)


PREVALANCE OF KNEE CHONDROCALSINOSIS IN PATIENT WITH PRIMARY KNEE OSTEOARTHRITIS IN RHEUMATOLOGY CLINICS OF IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES(2000-2001)
A Shafahi, F Ahmadi, S.h Poormoghim,
Volume 9, Issue 31 (3-2003)
Abstract
This observative study was aimed to assess the frequency of knee chondrocalcinosis in patients (pt.s) with knee osteoarthritis (OA), older than 40 years, came to rheumatology clinics. 65 pt.s with mean age of 59.3 years (SD=9.1206) and range of ages 42-81 years were collected. 56 of then female and rest (9) male. 9.23% [confidence Interval (CI) 3.46.19.01] had chondrocalcinosis and grade 4 OA according to kellgren classification, all older than 60 years. It showed a prevalence of 19.35% (CI: 7.45-37.47) for chondrocalcinosis above 60 years old, suggesting the increase of its incidence with advanced age and severity of OA. Among all pt.s (65) that 84.6% (CI: 73.5-92.36) of them had advanced OA. There were only 7.69%(CI: 2.5-17) of pt.s with bone cyst. The female to male ratio of OA was 6.2 to 1, showing the higher frequency in females, the same ratio of chondrocalcinosis was 2 to 1 showing the higher frequency in males. Only 10.77% (CI: 4.4-20.9) of all pt.s were smoke and nobody of pt.s with chondrocalcinosis were smoke. 87.7% (CI: 77.2-94.5) of pt.s with OA were overweight or obese. In pt.s with chondrocalcinosis (6), 1/3 of them were normal weight, 1/3 were overweight, and 1/3 were obese 61.5% (CI 48.6-73.3) of pt.s had buchard’s node or Heberden’s node or both, that showed the higher frequency of them primary OA. Most of the pt.s (66.15%) had isolated decreasing of articular space in medial tibiofemoral joint.
Abdominal Wall Tumor with Pathology of Sarcomatoid Transitional Cell Carcinoma Originating from Urachus: A Case Report And Literature Review
R Azizi, R Setareh Shenas, K Hosseini, Y Shafaee Khanghah,
Volume 13, Issue 50 (4-2006)
Abstract

    Introduction: We report a case of sarcomatoid transitional cell carcinoma of urachus in a 53-year-old man with unusual and very rare pathology. Case Report: The patient was operated for BPH a year before his admission. He complained from abdominal pain and palpable tumoral mass in left rectus muscle for five months. At follow-up, abdominal ultrasonography showed one semi echo mass in left rectus muscle. Then, abdominal and pelvic CT scan with double contrast study revealed asymmetric enlargement of the left rectus muscle. The density of the muscle was in homogeneous central hypodensity region. Suggestive of chronic resorbing hematoma, abscess or rare tumoral lesion, cystescopy showed no space occupying lesion in mucosa of bladder, but external pressure was identified in dome of bladder. The patient was operated with possibility of soft tissue tumor of abdominal wall and with high probability suspect for sarcoma or desmoids tumor. Post-operative pathological diagnosis was sarcomatoid transitional cell carcinoma of urachus. Conclusion: In review of the literature we found only one case with TCC of urachus, and to our knowledge no case of sarcomatoid TCC of urachus has been reported before.


Evaluation of morphology and immunophenotype of mesenchymal stem cells after switching of bovine serum of media to human serum
Hajar Shafaei, Ebrahim Esfandiari, Hassan Baghernezhad,
Volume 23, Issue 151 (1-2017)
Abstract

Background: Mesenchymal Stem Cells (MSCs) are used for cell therapy purposes. Fetal Bovine Serum (FBS) in culture media is essential for growth. As FBS may induce an immunological reaction and transfer pathogenic agents to MSC recipients, this study was designed to evaluate Adipose Tissue Stem Cells (ASCs) in FBS, human serum, switching of FBS to human serum and vice versa by cytology and flow cytometry.

Results: ASCs isolated and expanded in medium containing FBS were flat shape and slowly growing versus to those grown in medium containing human serum. The forward scatter data significantly demonstrated ASCs in FBS had large size as compared to others (p<0.05). Morphology of ASCs were similar to flow cytomertic findings. There are no significant differences in immunophenotypic markers of ASCs such as CD44, and CD90 grown in different media. However mean fluorescence intensity was higher for CD44 in human serum groups.

Conclusion: These results indicate that medium enriched with human serum improved the culture condition of ASCs in comparison with medium enriched with commercially available FBS. Switching of FBS to human serum may be a useful method for stem cells that are grown in medium containing FBS or frozen in FBS


Page 1 from 1     

© 2025 CC BY-NC-SA 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb