M Falahati, M Shabani, M.a Mirmohammad Ali Roodaki, F Jahanbani, K Pooshang Bagheri,
Volume 12, Issue 49 (3-2006)
Abstract
Background & Aim: NO(Nitric Oxide) is a lipophilic molecule which acts as a cytotoxic and mediator in the body. Also, NO has a role in cellular defense and its high concentration causes inhibition of growth and death of microorganisms such as fungi. This experimental study was designed to search the antidermatophilic effects of NO donors and their probable interactions with terbinafin. Material & Method: The method used in this study was determination of MIC(Minimum Inhibitory Concentration) in microdilution broth as per NCCLS(National Committee for Clinical Laboratory Standards) recommendations. Results: The results showed that inhibitory and cidal effects of NO donor complex on dermatophytes are significant. In comparison with terbinafin, its potency is very low and fungicidal effects of both are dependent on their concentration. The zoophilic and geophilic species are more sensitive to either terbinafin or DETA/NO(Diethylen triamine nitrite) than antropophilic ones. The interaction between DETA/NO and terbinafin for microsporom canis, microsporom gypseum, and trichophyton mentagropytes(non-antropophilic species) is because 14 is antagonist. As a result of short half-life of DEA/NO(Diethyl amine nitrite), no effects were observable in this study. Conclusion: Considering the obtained results and the literature, it seems that topical usage of NO donor complexes can be a useful treatment for dermatophitic infections.
M Falahati, M Shabani, M Mirmohammadali Roodaki, F Jahanbani, K Pooshang Bagheri,
Volume 13, Issue 51 (6-2006)
Abstract
Background & Aim: Nitric oxide(NO) is a molecule with expanded and numerous roles in biologic system of the body. It shows antitumor and antimicrobial activities. Stimulation of macrophages by different microorganisms leads to the production of a large amount of NO with toxic property that causes the death of microorganisms. Mechanisms related to NO perform an important role in host’s defense against fungal infections. In candidial infections NO is regarded as the most important factor in killing candida albicans by polimorphonuclear cells. Material & Method: This experimental study was designed to investigate antifungal potential of two NO donor complexes namely DPTA/NO(Dipropylenetriamine nitric oxide) and DEA/NO(Diethyleamine nitric oxide) per se and in combination with antifungal drugs such as ketoconazole and amphotricin B against candida albicans, candida parapsilosis, candida tropicalis, candida glabrata, and cryptococcus neoformans. In order to do so, we determined MIC(Minimum Inhibitory Concentration) and MFC(Minimum Fungicidal Concentration) of the above-mentioned complexes as per NCCLS(National Committee of Clinical Laboratory Standards) using microdilution broth method. Results: The obtained findings showed that DPTA/NO complex per se exerted antifungal effects. In addition, this complex revealed synergic effects on C. tropicalis, C. glabrata II, and cryptococcus neoformans(FIX<0.5) and additive effects on C. albicans, C. parapsilosis, and C. glabrata I(0.5
Alireza Jahanbani, Seyed Mohamad Ajjadi Dezfouli,
Volume 26, Issue 7 (10-2019)
Abstract
Aspartame as a synthetic sweetener is a dipeptide composed of aspartic acid and phenylalanine. It is 180 -200 times more sweetener than sucrose, which is made by two enzymatic and non-enzymatic methods and was first discovered randomly in 1965. The high sweetening power and low calorie of aspartame was prompted food industry that it used as a good alternative compared to sugar in sweet foods such as all types of beverages and sweets for people with diseases that associated with glucose homeostasis.
In several years ago, some studies have shown that aspartame has been considered as a reason for induction of oxidative stress, metabolic syndrome, nervous system diseases, modifier of gastrointestinal microflora, and complications that related to these and even cancer. While, in the other studies, aspartame is still considered as a safe compound and an alternative compared to sugar for prevention of diseases such as obesity, diabetes and weight loss.
Despite of contradictory studies, food safety organizations such as the FDA, the FAO, and the EFSA, are still authorizing daily use of aspartame at an acceptable daily intake (DAI) for all individuals with the exception of people with phenylctonuria disease.
