Mahshid Kadkhodaei Khalafi, Valiollah Dabidi Roshan, Mohammad Reza Beyranvand,
Volume 18, Issue 84 (6-2011)
Abstract
Background: Although a series of cardiovascular risk factors have been recently identified, taurine deficiency has been demonstrated as a risk factor for cardiovascular disease and has been poorly investigated in patients with Cardiac Heart Failure (CHF).The aim of present study was to investigate response of the cardiovascular physiological and functional markers following the short-term taurine supplementation and Burce protocol in patients with CHF.
Methods : In a semi-experimental design, sixteen male CHF patients (classified in class II & III) aged between 50 to 65 yr. were randomly divided into taurine and placebo groups. The taurine group received 1.5 gr. of taurine (3 times daily 500 mg capsules), while at the same time, the placebo group consumed starch capsules for duration of 2 weeks. Systolic and diastolic blood pressure, heart rate, maximal activity time on treadmill by Bruce protocol, Vo2 peak and plasma taurine, cardiac troponin I and CPK-MB concentrations were measured before and after taurine supplementation by standard methods. Data was analyzed by using dependent and independent t- student tests at p ≤ 0.05 levels.
Results: The results showed that the taurine supplementation decreased systolic and diastolic blood pressure level, heart rate and the cardiac troponin I and CPK-MB concentration in plasma, as compared with placebo group. In addition, taurine supplementation increased the maximal activity time on treadmill and Vo2 peak in comparison with placebo group.
Conclusion : These data proved the anti-hypertensive effect and antioxidant role of taurine in patients with CHF. Therefore, our study supports this idea that taurine supplementation can be recommended to patients who suffer from cardiac events as a preventive nutritional strategy.
Saied Kamal Sadat-Hoseini, - Valiollah Dabidi Roshan, - Mohadese Shojaeishahrokhababdi,
Volume 23, Issue 151 (1-2017)
Abstract
Background: The aim of this study was to investigate the pretreatment effects of time courses of training and different doses of medication in multiple organs (liver and heart) of rats treated with doxorubicin (DOX).
Methods: in this experimental study, Seventy-two Wistar male rats were randomly assigned to control and training groups with three subgroups: DOX 10mg/kg, DOX 20mg/kg and saline. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20 m/min, 5 days/week for 6 and 3 weeks. DOX and saline injection was performed 24 hr after the last exercise session, and tissue collection was done 24 hr after the injections.
Results: Acute administration of DOX 20mg/kg, caused a significant increase in Heat Shock Protein (HSP) and significant decrease in Catalase (CAT) and difference between two tissue (liver and heart) was significant. Six and three weeks training before DOX 20 mg/kg and DOX 10 mg/kg administration led to insignificant and significant increase in HSP, in the liver and heart, respectively. In addition, six weeks training before administration of different doses of DOX, led to significant increase in CAT in both tissue. Also, there was significant difference between two tissues after six and three weeks training.
Conclusion: The results of the present study represent that regular aerobic exercise, by increasing protective and antioxidant markers, can be prescribed as a pretreatment strategy against DOX-induced tissue toxicity (liver and heart).
Mr. Mehdi Nikseresht, Dr Valiolah Dabidi Roshan, Dr Mahmoud Nikseresht,
Volume 25, Issue 8 (Oct-Nov 2018)
Abstract
Background: Indices of lifestyle (i.e. physical health, exercise-fitness, nutrition, prevention of diseases, mental health, spiritual health, social health, avoid of drugs and narcotics, prevention of events and environmental health), blood pressure and cardiorespiratory fitness associated with coronary artery disease. However, there is limited research about which variables are important. Thus, the aim of this study to predict the heart failure (HF) with indices of lifestyle and physiological (systolic and diastolic blood pressure, ankle brachial index and peak oxygen uptake (VO2 peak).
Methods: The sample included 299 men (aged 50-77 -years) who referred due to heart problem to hospital. The Rose angina questionnaire was used to diagnosis of the HF. In addition, lifestyle and physical activity level questionnaires were completed by the subjects. The VO2 peak was estimated by non-exercise method.
Results: Multiple linear regression showed that the HF was significantly predicted based on lifestyle and physiological indices (R= 0.457, p= 0.0003). By step-by-step method, it was determined that social health, exercise-fitness and prevention of diseases factors were the most important in this prediction, respectively. Partial correlation showed that VO2 peak was inversely associated with HF (R= - 0.213, p= 0.0002), after adjustment for age, weight, body mass index and abdominal.
Conclusion: It seems that the social health, exercise-fitness and prevention of diseases compared with other factors are more effective for predicting the HF in men aged 50-77 years.
