Research code: 1234
Ethics code: 1234
Clinical trials code: 1234
Semnan University , m.hassanlou@semnan.ac.ir
Abstract: (54 Views)
The musculoaponeurotic fibrosarcoma (MAF) gene is a transcription factor that plays an important role in the growth and differentiation of many organs and tissues. The MAF gene plays a complex role in cancer, acting both as a potential oncogene and as a regulator of the immune response in the tumor microenvironment. Overexpression of this gene is seen in multiple myeloma and other cancers and affects the behavior of tumor cells and their interaction with surrounding immune cells. In this study, stem-loop structures like to microRNA precursors were identified in the MAF gene sequence using SSCprofiler software. The secondary structure of these structures was mapped using RNAfold software with minimum free energy for RNA sequencing. The sequences of mature microRNAs were identified using Mature Bayes software. Analysis of microRNA seq data confirmed the expression of the obtained microRNAs in tumor tissues. The results showed that the MAF gene has three miRNA sequences that are highly conserved among different organisms. Overall, the evidence suggests the existence of novel miRNAs encoded in the MAF gene. The presence of these miRNAs could explain some of the complexities of the MAF proto-oncogene function and may open new horizons for the medical community in the future in cancer treatment.
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