Razi Journal of Medical Sciences

    Background & Aim: Osteoarthritis(OA) is the most frequent disorder seen in the population and imposes a great financial load on the health systems worldwide. This issue necessitates more evaluations to elucidate factors influencing its incidence, severity or clinical presentations. The aim of the present study is to find out whether helicobacter pylori(H.pylori) seropositivity differs significantly in patients suffering from OA in comparison with healthy population. Patients and Method: In an analytic observational cross-sectional study, an enzyme-linked immunosorbent assay(ELISA) was used to detect H.pylori specific immunoglobulin G(IgG), immunoglobulin A(IgA) and antibodies against cytotoxin-associated-protein A(anti-Cag A) in 90 patients with OA referred to Baqiyatollah rheumatology clinic and 95 healthy control individuals. For data analysis independent t-test was used. Results: The average age was 53(±0.64) years for 84 women and 6 men in OA group and 39.67(±1.12) years for 78 women and 17 men in the control group. Mean serum IgA level was 40.3(±3.75) and 27.26(±2.05) for OA and control groups respectively. In our evaluation this disparity was statistically significant(P=0.003). Anti H.pylori IgG serum level was not significantly higher in patients with OA in comparison with healthy individuals(P=0.128). Also, anti-CagA antibody serum level did not show a significant difference between OA and control groups(P>0.05). Conclusion: Serum level of anti H.pylori IgA antibody was significantly higher in patients with OA than healthy individuals(p=0.003). This finding was not true for anti-Cag A and IgG antibodies.