Razi Journal of Medical Sciences

    Background & Aim: Wound healing is the restoration of physical integrity to internal and external structures and involves intricate interactions between the cells and numerous other factors. Appropriate treatment and care is essential to accelerate healing process, prevent infection and chronicity of the wound and different means and approaches have thus far been used to this end. The aim of this study was to evaluate the effect of aluminium hydroxide, that was used for prevention of bed sore primitively, on the wound healing process in rat. Material and Methods: The effect of aluminium hydroxide on the healing process in two model skin wounds long wounds of 15 mm-long full-thickness and round wounds of 15mm diameter full thickness incision given in the paravertebral area, 1.5mm from midline on the back of rats which was evaluated through measuring the length and area of the healed region with pathological evaluation on different days. Also conducting tensiometry experiments were conducted after complete wound healing. Results: 1. The percentage of wound healing on days 3, 6, 9, 12 and 15 in control group of long wounds changed in the group treated with aluminium hydroxide from 10.13%, 31.88%, 52.46%, 78.75% and 100% to 10.25%, 33.38%, 55.38%, 81.36% and 100% respectively also the percentage of wound healing on days 3, 6, 9, 12, 15 and 18 in control group of round wounds changed in the group treated with aluminium hydroxide from 9.88%, 21.25%, 52.13%, 69.63%, 88.21% and 100% to 10.28%, 29.50%, 52.38%, 75%, 91.73% and 100% respectively. 2. Stress(maximum tensile force causing skin rupture) changed from 13.19 Neuton(N) in the control group of long wound to 15.11 N, also from 11.78 N in the control group of round wound to 11.94 N in group treated with aluminium hydroxide. 3. Strain(tissue length under maximum strain) changed from 9.98 mm in the control group of long wound to 10.59 mm, also from 10.53 mm in the control group of round wound to 11.57 mm in group treated with aluminium hydroxide. 4. The result of patological samples in control and aluminium groups in long and round wounds were nearly similar in regard to healing process, cellular aggregates and clearing of wound area considering the time sequence of samples stained with Hemotoylin and Eosin(HE) Conclusion: Our findings suggest that probably aluminium hydroxide has no effect on skin wound healing process and collagen synthesis in rat, however more immunohistochemical studies are needed.