Volume 30, Issue 6 (9-2023)
RJMS 2023, 30(6): 0-0 |
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Research code: 162353984 : در سامانه پژوهشیار
Ethics code: IR.IAU.M.REC.1399.008
Clinical trials code: IR.IAU.M.REC.1399.008
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Zolghadri V, Barari A, Abbasi daloii A, Abed Natanzi H. The effect of aerobic training and nettle extract on the gene expression of IL-8 and Tumor volume in mice with melanoma cancer. RJMS 2023; 30 (6)
URL: http://rjms.iums.ac.ir/article-1-7552-en.html
URL: http://rjms.iums.ac.ir/article-1-7552-en.html
Associate Professor Islamic Azad University, Iran - - Department of Sport Physiology, Ayatollah Amoli Branch
Abstract: (250 Views)
Background: Melanoma cancer is one of the most common types of skin cancer. In this cancer, skin cells grow uncontrollably and divide rapidly. The aim of this study was to evaluate the effect of nettle extract consumption and aerobic exercise on IL-8 and Tumor volume gene expression in mice with melanoma.
Methodology: In this experimental study, 20 adult male rats with weighing 300 to 350 g were randomly divided into 4 groups, including groups of: control, exercise, extract and exercise + extract. The training program consisted of 30 minutes of running on a treadmill without a slope at a speed of 16 meters per minute for the first week, and one meter per minute was added every week until it reached 22 meters per minute in the eighth week. One week after induction of melanoma cancer and through implantation of the tumor under the skin, the experimental group consumed 30 mg / kg / day of nettle ethanol extract orally for 8 weeks. RT PCR was used to measure the expression of IL-8gene.
Results: The results of the present study showed that consumption of nettle extract and aerobic exercise significantly reduced the expression of interleukin 8 in the experimental groups compared with the control group (p = 0.125, p = 0.278, = 0.174, respectively. p). The results also showed that tumor volume was significantly reduced among the experimental groups compared to the control group (p = 0.021, p = 0.136, p = 0.047, respectively).
Conclusion: The data of the present study show that regular activity and consumption of nettle extract can play a therapeutic role in melanoma cancer by reducing the expression of interleukin 8 and tumor volume.
Methodology: In this experimental study, 20 adult male rats with weighing 300 to 350 g were randomly divided into 4 groups, including groups of: control, exercise, extract and exercise + extract. The training program consisted of 30 minutes of running on a treadmill without a slope at a speed of 16 meters per minute for the first week, and one meter per minute was added every week until it reached 22 meters per minute in the eighth week. One week after induction of melanoma cancer and through implantation of the tumor under the skin, the experimental group consumed 30 mg / kg / day of nettle ethanol extract orally for 8 weeks. RT PCR was used to measure the expression of IL-8gene.
Results: The results of the present study showed that consumption of nettle extract and aerobic exercise significantly reduced the expression of interleukin 8 in the experimental groups compared with the control group (p = 0.125, p = 0.278, = 0.174, respectively. p). The results also showed that tumor volume was significantly reduced among the experimental groups compared to the control group (p = 0.021, p = 0.136, p = 0.047, respectively).
Conclusion: The data of the present study show that regular activity and consumption of nettle extract can play a therapeutic role in melanoma cancer by reducing the expression of interleukin 8 and tumor volume.
Type of Study: Research |
Subject:
Exercise Physiology
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