Razi Journal of Medical Sciences

Background: Aging is a process in which structural and functional changes occur in the heart. This study was performed to compare aerobic and resistance training on some oxidative markers and TGF-β in cardiac tissue of elderly rats.
Methods: For this experimental study, 27 Wistar rats (mean age 24 months) were randomly divided into three groups of control (9 rats), resistance training (9 rats) and endurance training (9 rats). After one week of endurance training, rats in the endurance group performed their training on a zero-degree steep treadmill for 8 weeks and 2 days a week. Resistive exercise group also performed on the ladder for eight weeks and seven days a week. The research variables were measured by ELISA using Zellbio Germany kits. Data were analyzed using one-way analysis of variance.
Results: In the present study, it was found that the effect of eight weeks of aerobic and resistance training on GPX (p=0.005), SOD (p=0.002) and TGF-β (p=0.005) was significant in the heart tissue of elderly rats. As a result of the post hoc test, it was found that there was only a difference between the experimental and control groups.
Conclusion: The results of this study indicate the role of aerobic and resistance training in improving oxidative stress indices in the heart tissue of elderly rats.