Volume 26, Issue 10 (12-2019)
RJMS 2019, 26(10): 1-7 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Kazemi-Lomedasht F, Behdani M, Shahbazzadeh D. Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line. RJMS 2019; 26 (10) :1-7
URL: http://rjms.iums.ac.ir/article-1-5707-en.html
URL: http://rjms.iums.ac.ir/article-1-5707-en.html
Pasteur Institute of Iran, Tehran, Iran , fa_kazemi@pasteur.ac.ir
Abstract: (2831 Views)
Background: Breast cancer is one of the most related cancer deaths among women. The scorpion venom consists of various peptides and proteins with cytotoxic, apoptotic and growth inhibitory effects on various cancers. Studying the cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line was the main aim of this study.
Methods: The T47D cells were cultured as monolayer in RPMI1640 medium. The toxicity of the scorpion venom on T47D cell line was evaluated by MTT assay and the IC50 was calculated. The HEK293 cell line was used as control cell line. Results: The MTT assay results showed the time and dose-dependent inhibitory effect of H. lepturus venom on T47D cell line. However, such effect was not observed on HEK293 cell line in identical dose.
Conclusion: The achieved results indicate the anticancer effect of H. lepturus venom on T47D breast cancer cell line.
Methods: The T47D cells were cultured as monolayer in RPMI1640 medium. The toxicity of the scorpion venom on T47D cell line was evaluated by MTT assay and the IC50 was calculated. The HEK293 cell line was used as control cell line. Results: The MTT assay results showed the time and dose-dependent inhibitory effect of H. lepturus venom on T47D cell line. However, such effect was not observed on HEK293 cell line in identical dose.
Conclusion: The achieved results indicate the anticancer effect of H. lepturus venom on T47D breast cancer cell line.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
