Volume 12, Issue 49 (3-2006)                   RJMS 2006, 12(49): 63-70 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rasi A, Safaii Naraghi Z, Tavangar S, Taghizadeh A, Davoodi F. Angiogenesis Evaluation in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma. RJMS 2006; 12 (49) :63-70
URL: http://rjms.iums.ac.ir/article-1-541-en.html
Abstract:   (7613 Views)

    Background & Aim: Tumour angiogenesis is essential for tumour growth and appears to play an important role both in invasive growth and metastasis. Basal cell carcinomas(BCCs) and squamous cell carcinomas(SCCs) of the skin are derived from a similar cell type but differ in the invasive and metastatic potential. This study investigates whether the behaviour of these tumours could be explained by differences in their angiogenesis patterns. Material & Method: Vessel counts were made of blood vessels in the stroma and the body of 32 BCCs, 15 SCCs, and 4 normal skin samples, both after H&E(Hematoxylin and Eosin) and immunohistochemical staining using CD31 monoclonal antibody. Results: The stromal(P<0.0001) and body(P<0.0001) counts for SCCs differed significantly from the counts for BCCs. There was a correlation between the vascular density and degree of differentiation in SCC samples(P=0.002). The stromal(P<0.0001) and body(P<0.0001) counts for BCCs differed significantly in invasive and non-invasive groups. Conclusion: The microvascular density is correlated with invasive growth pattern and metastasis of skin SCCs and BCCs. It seems that the vessels in the tumour body play a more important role.

Full-Text [PDF 373 kb]   (5556 Downloads)    
Type of Study: Research |

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb