Razi Journal of Medical Sciences

    Fibro-Osseous lesions are numerous and heterogeneous group of tumors of the jaws which pose difficulties on classification, diagnosis and treatment. The present study was undertaken to evaluate fibrous dysplasia and the diagnostic value of histologic examination for its workup. Fifteen patients with cranio-facial bone lesion, who had previous pathologic diagnosis of fibrous dysplasia, were evaluated during 4 years (1998-2002) in Hazrat Fatemeh Hospital. Male-female ratio was 9/6 and patients’ range of age was between 16-38 years with mean age of 20 years. There were 12 patients with monostotic and 3 patients with multiple lesions of both jaws and skull. The maxilla bone was the most frequent site of the lesion. Clinicopathologic diagnostic correlation was 46.6%. There was one patient with malignant transformation of the lesion to osteogenic sarcoma. In microscopic view, 10 cases were classic fibrous dysplasia with evenly distributed islands of woven bone without osteoblastic rimming in a fibroblastic stroma, 5 cases showed variation in histologic pattern, 3 cases had focal or diffused osteoblastic rimming(ossifying fibroma) and 2 cases had rounded bodies regarded as a form of cementum both contained cellular stroma exhibiting mitotic activity named as cemento-ossifying fibroma. These two lesions showed more local aggressiveness and bone deformity in clinical and radiologic study than in classic fibrous dysplasia.