Razi Journal of Medical Sciences

    A potential relationship between chronic infection with chlamydia pneumonia (CP) and atherosclerosis has been suggested by seroepidemiologic, pathologic and animal studies. The aim of the present study was to evaluate the relation between antichlamydia antibody in patients with coronary events. This research was performed as a retrospective, case-control study on the blood samples from 87 individuals in three group: 29 individuals with acute myocardial infarction, 29 with chronic stable angina and 29 healthy individuals in control group. These 3 groups were matched in terms of age, sex and major cardiovascular risk factors. After assembling samples, IgG antibody concentration against CP was measured in the sera by Elisa and based on the used kit. Serum antibody ranges higher than or equal to 5 unit per milliliter were considered as positive. Data analysis was carried out via Instat software, one-way ANOVA, and K² test with statistical significant level of P<0.05. In group with acute myocardial infarction, seropositivity to CP was 100%, in group with chronic stable angina 65.5% and in control group was 30%. These differences were statistically significant with P<0.001. Mean antibody levels were 34.7, 11.4 and 3.61u/ml respectively and the difference between these 3 levels was significant (P<0.001). These results show that anti CP antibody can be seen in a considerable number of patients with coronary artery disease. Also, CP antibody level is expected to have a positive correlation with coronary events including acute myocardial infarction.