Razi Journal of Medical Sciences

The present study was undertaken to analyze the status of immune system (responses & deficiencies) in children with Giardiasis aged between 2 to 9 years for probable correlation between blood serum & cellular elements and Giardiasis infection. With approval of Giardiasis through utilizing classic laboratory methods within parasitologic domains, blood samples of the affected children with Giardiasis underwent precise laboratory analysis with regard to blood cells counts (lymphocytes, monocytes, polynuclear cells, and blood white cells) and serum factors (immunoglobulins & complement components). These examinations showed that blood of the affected children with Giardiasis has a significant reduction in view of lymphocyte and monocyte, whilst otherwise, white cells and polynuclear cells showed no significant alterations. Similarly, serum analysis defined significant reduction in C3 and C4 complement components. In contrast, despite observing insignificant alterations in amount of IgG, serum level of IgE, IgM, IgA immunoglobulins increased significantly. These alterations may be related to cellular immune function (reactions), helper T cells (Th1), monocytes and complement system. On the contrary, helper T cells (Th2) functions and subsequently humoral immune response in patients with Giardiasis were normal and showed no disorder.