Razi Journal of Medical Sciences

Background: Increase and decrease of some hormones in the body and accumulation in breast tissue, can increase the risk of breast cancer. The purpose of this study was to examine the effects of eight weeks aerobic training on the sexual hormone binding globulin, insulin-like growth hormone-1 and lipoproteins in patients with breast cancer.

Methods: Twenty four women aged 45-55 years with breast cancer were selected and randomly divided into two groups: aerobic training (n=12) and control (n=12). Training group participated in an 8 weeks aerobic training program, three days a week and 60-90 minutes each day. In this period, the control group performed no regular exercise. Blood samples were taken before and after 8 weeks. Data were analyzed using independent T- test.

Results: The results showed that there were significant differences between two groups in SHBG (Sex hormone-binding globulin), LDL (Low-density lipoprotein) and total cholesterol prior and post eight weeks of aerobic exercise training. Exercise also significantly reduced exercise group’s weight (p=0.001) compared with the controls.