Background : The aim of this research was to determine the relationship between respiratory (Maximal voluntary ventilation (MVV) and vital capacity (VC) and inflammatory (Fibrinogen and C-reactive protein (CRP) and Creatine kinase (CK) markers in response to incremental exercise in 14-16 years old boys.

  Methods : Twenty four healthy boys aged 14-16 years participated in this study. The subjects were randomly assigned to trained (n=12) and control (n=12) groups. Blood samples were taken in baseline and immediately 2 minutes after exercise in trained group and in baseline and 48 hours later from the controls. Also paired t-test, t-test and linear regression methods were used for statistical analysis of the data.

  Result s: The CRP, MVV and Fibrinogen were significantly increased in the trained group (p≤0.001). The trained group had high level of the aforementioned markers compared with controls (p≤0.001). The Ck level was insignificantly decreased in the trained group (p≤0.001). The association between CRP and fibrinogen and CK with VC were significant in the trained group (p≤0.05).

  Conclusion : The incremental exercise shows a strong relationship between some inflammatory markers and respiratory parameters in adolescents aged 14-16 years.