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URL: http://rjms.iums.ac.ir/article-1-2779-en.html
Background:Amyloid-beta (Aβ), is one of the
risk factors of Alzheimer’s disease (AD) that increases in diabetes. The aim of
this study was to investigate the effect of 6 weeks of voluntary wheel running
with Allium paradoxum supplementation on plasma Amyloid beta1-42 in
the diabetic rats induced with Alloxan.
Methods: In this
laboratory experimental study 28 male ratsweighing 185±1 gm were randomly
assigned to 4 groups: control, training, Allium, and Allium-training. Diabetes
was induced with injecting Alloxan (120 mg/kg dissolved in saline)
peritoneally. The
traininggroup participated in voluntary wheel running for 6 weeks.
Results:Sixweeks of
voluntary wheel running significantly increased the plasma Aβ1-42 levels
in training group compared with control group (P<0.001). Also Aβ1-42
levels increased in training-Allium group in comparison with control group
(P=0.029) and Allium (P=0.025). Nevertheless, plasma Aβ1-42 levels
was not different between training-Allium and training (P=0.210) and Allium
(P=0.944) groups.
Conclusion:The plasma
Aβ1-42 levels of diabetic subjects was increased following 6 weeks of voluntary exercise combined with Allium
Paradoxum extract supplementation, but understanding the beneficial effects of
this increase in plasma Aβ1-42 levels requires more studies.
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