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URL: http://rjms.iums.ac.ir/article-1-2389-en.html
, Fariba Haydari Kohan , Farzaneh Ahmadi , Mehrdad Asadi , Fariba Fallahi , Zaynab Ghasemi , Mehraban Falahati
Background: Nystatin is a polyene with antifungal effect which is used in treatment of cutaneous
and mucocutaneous candidiasis in diverse forms. Increasing its utilization in
recent years has led to predominant increasing of resistances. Nowadays for
increasing of antifungal effect and decreasing of resistance and side effects
of drugs they are used in combination with each other. So we decided to
investigate antifungal effect of Nystatin in combination with nanosilver
particles.
Methods: This was an experimental study which has been
accomplished on 30 samples of isolated candida species from patients effected
to chronic candidal vaginitis. In this study the antifungal effects of Nystatin
and silver nanoparticles each of them alone and in combination with each other by
microdilution broth, were examined. Findings were described on the base of
logestic regression and man-vitni exam.
Results: Findings suggested that Nystatin was able to
inhibit the growth of candida species at an expanded range of concentration
between 16-128 microgeram per milliliter. As well antifungal activity of
Nystatin with silver nanoparticles was increased in comparision with using
Nystatin alone.
Conclusion: Introduce of nanosilver in drug formation of
Nystatin can be useful in treatment of chronic vaginal candidiasis.
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