Razi Journal of Medical Sciences

  Background : Studies show that there is association between Salvia officinalis extract administration and liver and heart functions. The main aim of this study was to determine the effects of Salvia officinalis extract on serum level of creatine kinase and alkaline phosphatase in male rats.

  Methods : In this laboratory experimental study, m ale wistar rats were randomly divided into control, normal saline receiving and Salvia officinalis extract (100, 150 or 200 mg/kg/day) receiving animals of 5 in each group. After a period of 6 weeks, blood samples were collected using cardiac puncture method. Following serum collection, serum creatine kinase and alkaline phosphatase levels were measured by spectrophotometry method. Data were statistically analyzed and compared between groups using ANOVA.

  Results : The results indicated that serum creatine kinase level was significantly decreased in rats receiving Salvia officinalis extract (100 mg/kg/day) compared with control animals (p<0.001). However, daily administration of Salvia officinalis extract (150 or 200 mg/kg) could not significantly change serum creatine kinase level. Serum alkaline phosphatase levels were significantly increased in animals receiving Salvia officinalis extract (100, 150 or 200 mg/kg/day) as compared with control rats.

  Conclusion : Our findings show that Salvia officinalis extract is enhancer of serum alkaline phosphatase and daily administration of the extract is serum creatine kinase reducer. However, such effect is dose dependent, according to which, repairing or impairing effect of the extract on certain tissues is conceivable.