Razi Journal of Medical Sciences

Unexplained infertility is considered when with application of standard investigations, including semen analysis, post coital test, endometrial biopsy, hysterosalpingography, and laparoscopy, etiologic factors are not found. With advances in science and technology and taking advantage of various assessment procedures especially during the last two decades, the prevalence of this entity is decreasing and at present it is about 10% .

In this paper first the new diagnostic procedures such as sperm function tests, histochemical and immunohistochemical studies of endometrium, immunological studies and then various treatment methods including: ovarian hyperstimulation, intra uterine insemination, and intra fallopian gamete (zygote) transfer are described.