Razi Journal of Medical Sciences

In last few years, numerous observations and studies on pathogenesis of spondyloarthropathies have been published and an animal model which confirms the associations of new information is now available. Bacteria which are responsible for reactive arthritis all can remain in the cells for long time. Molecules of class I MHC are able to present the intracellular peptides to immune system. B27 molecule can bind a special group of peptide«. A model of binding B27 to one or series of pathogenic peptide: (or srthritogenk: peptides) has been described. Class I molecules of MHC region can bind to the peptides and initiate an immune reaction or in selecting the T cell repertoire during T cell development in thymus. Recognition of subtypes of B27 molecule and the racial distribution of them has helped to better understanding of association of this antigen with spondyloarthropathies.

The relation of spondyloarthropathies with intestine and various theories about the role of B27 and development of spondyloarthropathies are also described in this article.