Volume 30, Issue 6 (9-2023)                   RJMS 2023, 30(6): 0-0 | Back to browse issues page

Research code: 1400-1-233-52935
Ethics code: IR.TUMS.NI.REC.1400.015
Clinical trials code: A-10-7192-1rt

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Fahanik babaei J. Investigation of repeated exposure effects to ketamine during preadolescence on neurobehavioral disorder and oxidative stress outcomes in adult male and female wistar rats. RJMS 2023; 30 (6)
URL: http://rjms.iums.ac.ir/article-1-7856-en.html
Abstract:   (228 Views)
Introduction: Repeated exposure to anesthesia in pre-adolescence is necessary for some therapeutic interventions. These exposures to general anesthetics during pre-adolescence can induce cognitive and behavioral problems, and later neurobehavioral problems in adulthood. The current study was aimed at providing morphological and functional evaluations of the long-term impacts of repeated ketamine exposure pre-adolescence and effects of in adulthood in male and female rats.
Methods: Thirty-two pre-adolescence male and female rats were randomly divided into four group: control male and female, repeat exposure to ketamine (20mg/kg/ip/daily/14 days) male and female groups. All animals received care for 30-35 days after last injection, then the influence on cognitive functions of repeated exposure to ketamine were tested using the Morris water maze and open field.
After behavior tests, Animals have sacrificed and their brain isolated and after homogenate, oxidative stress factors was assay.
Results: The analysis of Morris water maze and open field maze data indicated a significant difference in special memory impairment and anxiety levels in control group animals compared to ketamine induced. The results of oxidative stress revealed that there was a significant decrease in the activity of the superoxide dismutase enzyme between the groups, but there was no significant difference in the amount of glutathione between the control and ketamine receiving groups.
Conclusion: Our results indicated that repeated exposure to ketamine during pre-adolescence can cause neurobehavioral problems later in adulthood. These results may provide a new perspective for understanding the mechanism of repeat exposure of ketamine and its toxic effects in clinical.
Type of Study: Research | Subject: Anesthesiology

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