Volume 15, Issue 59 (summer 2008)                   RJMS 2008, 15(59): 39-46 | Back to browse issues page

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Amir Mozaffari, N, Forouhesh Tehrani, H, Tavaf Langeroodi, Z, Abdullahi, A. A Survey of Drug Resistance Due to Extended Spectrum Beta Lactamases (ESBLs) in Escherichia Coli Strains Isolated from Hospitalized Patients. RJMS. 2008; 15 (59) :39-46
URL: http://rjms.iums.ac.ir/article-1-1002-en.html
Abstract:   (7142 Views)

Background & Aim:

clinical cases especially from hospitalized patients. Recently multiple drug resistant

isolated from clinical cases. Resistances were seen against drugs belonging to different antibiotic families. In this

survey, drug resistance in clinical isolates was studied with special reference to extended spectrum beta


Escherichia coli is one of the most important and prevalent bacteria isolated fromE.coli strains have been

Patients and Method:

for drug resistance by disc diffusion method. The minimal inhibitory concentration (MIC) of isolates resistant to

different antibiotics was determined by E-test. Beta lactamases production was tested with nitrocephin disc and

extended spectrum beta lactamases assays were performed with double disc synergy tests. Finally, Chi-square

and t-tests were used to analyze the data.

A total of 113 E. coli strains isolated from hospitalized patients were initially surveyed


these MDR strains were positive in nitrocephin test, indicating beta lactamases production. Double disc synergy

tests results showed production of extended spectrum beta lactamases in all MDR isolates.

From the total of 113 E.coli isolates tested, 47 (41.5%) showed multi drug resistant trait. All of


Detection of 41.5% MDR trait, especially extended spectrum beta lactamases, in the clinical


cephalosporins. It also necessitates conduction of a wider study to determine the extent of MDR

isolates points to the potential dangers posed by the widespread usage of extended spectrumE.coli

occurrence at national level.

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Type of Study: Research | Subject: Microbiology

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