Volume 28, Issue 6 (9-2021)                   RJMS 2021, 28(6): 0-0 | Back to browse issues page

Research code: 98-4-70-16573
Ethics code: 16188
Clinical trials code: پژوهش کارآزمایی بالینی نبوده

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Hooman N, Honarpisheh P, Hasan O, Rozita H. Role of Urinary CD80 Biomarker in pediatric nephrotic syndrome. RJMS. 2021; 28 (6)
URL: http://rjms.iums.ac.ir/article-1-6623-en.html
Iran university of medical science , hooman.n@iums.ac.ir
Abstract:   (226 Views)
Abstract
Background: Nephrotic syndrome (NS) is one of the most common kidney diseases in children. In some cases of this disease, to achieve a reliable diagnosis and determine the prognosis and select the most appropriate treatment, kidney biopsy is necessary. Given that this method is invasive, one of the major challenges modern nephrology should face is the identification of biomarkers that are associated with the above. Advancements in the understanding of the pathogenesis of nephrotic syndrome have facilitated the identification of a growing number of molecules that might be useful for these objectives. One of these biomarkers is the CD80 molecule, which is a circulating molecule in nephrotic syndrome and can be found in kidney tissue or excreted in the urine. By measuring its urinary level, it is possible to diagnose a specific type of nephrotic syndrome. In this article we reviewed different studies have been conducted on the role of CD80 in nephrotic syndrome.
Methods: In this review article, studies on the role of CD80 in nephrotic syndrome in children from 2002 to 2020 have been reviewed. This review has been done by searching in Cochrane, Scholar Google, and PubMed search engines. Review articles and case reports were excluded from the study.
Results:  CD80 is normally expressed on antigen-presenting cells (APC). Recent studies have indicated that podocyte cells in certain circumstances can acquire the phenotype of APC and can be induced to express the CD80 (B7.1) molecule. It has been shown that the expression of CD80 in podocytes is associated with the rearrangement of actin in them and increases their permeability to protein. Most studies support its role as a permeability factor in minimal change nephrotic syndrome(MCD), that was significantly elevated in the active phase of MCD but remained to be normal in the active and remission phases of other types of nephrotic syndrome and in the remission phase of MCD. A recent study has reported that high urinary CD80 excretion might be a biomarker for steroid responsiveness and a predictor for good prognosis in NS.
Conclusion: CD80 molecule can be used as a valuable non-invasive biomarker to differentiate MCD-relapse from other glomerulopathies and also predicts steroid responsiveness and good prognosis in patients with nephrotic syndrome.Abstract
Background: Nephrotic syndrome (NS) is one of the most common kidney diseases in children. In some cases of this disease, to achieve a reliable diagnosis and determine the prognosis and select the most appropriate treatment, kidney biopsy is necessary. Given that this method is invasive, one of the major challenges modern nephrology should face is the identification of biomarkers that are associated with the above. Advancements in the understanding of the pathogenesis of nephrotic syndrome have facilitated the identification of a growing number of molecules that might be useful for these objectives. One of these biomarkers is the CD80 molecule, which is a circulating molecule in nephrotic syndrome and can be found in kidney tissue or excreted in the urine. By measuring its urinary level, it is possible to diagnose a specific type of nephrotic syndrome. In this article we reviewed different studies have been conducted on the role of CD80 in nephrotic syndrome.
Methods: In this review article, studies on the role of CD80 in nephrotic syndrome in children from 2002 to 2020 have been reviewed. This review has been done by searching in Cochrane, Scholar Google, and PubMed search engines. Review articles and case reports were excluded from the study.
Results:  CD80 is normally expressed on antigen-presenting cells (APC). Recent studies have indicated that podocyte cells in certain circumstances can acquire the phenotype of APC and can be induced to express the CD80 (B7.1) molecule. It has been shown that the expression of CD80 in podocytes is associated with the rearrangement of actin in them and increases their permeability to protein. Most studies support its role as a permeability factor in minimal change nephrotic syndrome(MCD), that was significantly elevated in the active phase of MCD but remained to be normal in the active and remission phases of other types of nephrotic syndrome and in the remission phase of MCD. A recent study has reported that high urinary CD80 excretion might be a biomarker for steroid responsiveness and a predictor for good prognosis in NS.
Conclusion: CD80 molecule can be used as a valuable non-invasive biomarker to differentiate MCD-relapse from other glomerulopathies and also predicts steroid responsiveness and good prognosis in patients with nephrotic syndrome.Abstract
Background: Nephrotic syndrome (NS) is one of the most common kidney diseases in children. In some cases of this disease, to achieve a reliable diagnosis and determine the prognosis and select the most appropriate treatment, kidney biopsy is necessary. Given that this method is invasive, one of the major challenges modern nephrology should face is the identification of biomarkers that are associated with the above. Advancements in the understanding of the pathogenesis of nephrotic syndrome have facilitated the identification of a growing number of molecules that might be useful for these objectives. One of these biomarkers is the CD80 molecule, which is a circulating molecule in nephrotic syndrome and can be found in kidney tissue or excreted in the urine. By measuring its urinary level, it is possible to diagnose a specific type of nephrotic syndrome. In this article we reviewed different studies have been conducted on the role of CD80 in nephrotic syndrome.
Methods: In this review article, studies on the role of CD80 in nephrotic syndrome in children from 2002 to 2020 have been reviewed. This review has been done by searching in Cochrane, Scholar Google, and PubMed search engines. Review articles and case reports were excluded from the study.
Results:  CD80 is normally expressed on antigen-presenting cells (APC). Recent studies have indicated that podocyte cells in certain circumstances can acquire the phenotype of APC and can be induced to express the CD80 (B7.1) molecule. It has been shown that the expression of CD80 in podocytes is associated with the rearrangement of actin in them and increases their permeability to protein. Most studies support its role as a permeability factor in minimal change nephrotic syndrome(MCD), that was significantly elevated in the active phase of MCD but remained to be normal in the active and remission phases of other types of nephrotic syndrome and in the remission phase of MCD. A recent study has reported that high urinary CD80 excretion might be a biomarker for steroid responsiveness and a predictor for good prognosis in NS.
Conclusion: CD80 molecule can be used as a valuable non-invasive biomarker to differentiate MCD-relapse from other glomerulopathies and also predicts steroid responsiveness and good prognosis in patients with nephrotic syndrome.
     
Type of Study: review article | Subject: Pediatric Nephrology

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