Volume 27, Issue 12 (2-2021)                   RJMS 2021, 27(12): 0-0 | Back to browse issues page

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Nazarpour S, Ramezani Tehrani F. Maternal weight gains and thyroid function; a narrative study. RJMS. 2021; 27 (12)
URL: http://rjms.iums.ac.ir/article-1-6331-en.html
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , fah.tehrani@gmail.com
Abstract:   (95 Views)
Background and Aim: Maternal weight gain can affect pregnancy outcomes; several factors influence this effect. Maternal thyroid function also appears to influence maternal weight gain and may have adverse effect on maternal and neonatal outcomes. Studies on the relationship between maternal thyroid function and weight gain during pregnancy are limited in this review study, we summarized the studies assessed the effect of maternal thyroid function on maternal weight gain.
Methods: In this systematic review, the PubMed, Web of Science and Scopus, as well as SID, Irandoc, and Magiran (Persian databases) were searched with appropriate keywords for the English and Persian related articles up to March 2020. In the current review, of 121 records retrieved through primary searching databases, 5 eligible studies were evaluated.
Results: Maternal weight gain in early pregnancy largely reflects maternal fat deposition, and in mid- and late pregnancy reflects increased maternal fluid and amniotic fluid and fetal, placental and uterine growth. Studies have shown that maternal thyroxin (FT4) levels have a significant relationship with maternal fat reserves, and lower FT4 levels in mid-pregnancy have been associated with an increased risk of over weight gain during pregnancy. Changes in leptin levels are associated with weight gain and may affect thyroid function via hypothalamic-pituitary-thyroid stimulation. Studies of the association of high body mass index (BMI) with maternal FT4 may also be explained by the effect of human chorionic gonadotropin (hCG).
Conclusions: There is insufficient data on the relationship between maternal thyroid function during pregnancy and maternal weight gain, and the underlying mechanisms are unclear. The effect of thyroid hormones on maternal weight gain seems to be implemented through several biological pathways and seems to be a two-way effect. While thyroid function has a clear effect on basal metabolism and can affect fat stores, on the other hand, maternal weight gain may lead to altered thyroid function. Further studies are needed in this area.
     
Type of Study: review article | Subject: Gynecology

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