Volume 28, Issue 1 (3-2021)                   RJMS 2021, 28(1): 0-0 | Back to browse issues page

Research code: NO.19.33.2018
Ethics code: NO.19.33.2018
Clinical trials code: NO.19.33.2018

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Abdizadeh L, peeri M, Azarbayjani M A, Farzanegi P. The effect of aerobic exercise, mesenchymal stem cells(MSCs) and ozone therapy on anxiety and like depression behaviors caused by induction of osteoarthritis in rats. RJMS. 2021; 28 (1)
URL: http://rjms.iums.ac.ir/article-1-6328-en.html
Department of Physical Education and Sport Sciences, Islamic Azad University, Central Tehran Branch, Tehran, Iran. , m.peeri@iautcb.ac.ir
Abstract:   (147 Views)
Introduction: Osteoarthritis affects emotional performance by reducing a personchr(chr('39')39chr('39'))s performance, so the present study aimed to investigate the effect of exercise, MSCs and ozone on anxiety and like depression behaviors caused by induction of osteoarthritis in rats.
Methods: 40 rats after induction of osteoarthritis in 8 groups 1) control, 2) MSCs, 3) exercise, 4) ozone, 5) exercise+ozone, 6) exercise+MSCs, 7) ozone+MSCs and 8) Exercise+ozone+MSCs. Also, to investigate the effects of induction of osteoarthritis on research variables, 5 rats were included in the healthy control group.    
In 8 weeks, groups 3, 5, 6, and ran on a treadmill for 3 sessions per week, groups 2, 6, 7, and 8 received 1× 106cells/kg, and groups 4, 5, 7, and 8 ozone in 3 Repeat and receive 20 µg/ml before starting the exercise, and then the open field test was performed.
Results: Induction of osteoarthritis led to anxiety and like depression behaviors (P0.05). However, exercise+MSCs significantly reduced circulation in the environment and significantly increased circulation in the center (P0.05); exercise, ozone, and MSCs each alone, exercise+ ozone, and exercise+MSCs significantly increased the overall distance traveled (P0.05).
Conclusion: It seems that exercise, MSCs and MSCs+ozone reduce the anxiety caused by the osteoarthritis model. Also, exercise, ozone, MSCs each alone, exercise+ozone and exercise +MSCs have more favorable effects on reducing depression.
Type of Study: Research | Subject: Exercise Physiology

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