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جلد 26 شماره 8 صفحات 55-42 |
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Sahraei S S, Kalhor N, Sheykhhasan M. Application of scaffolds in cartilage tissue engineering: a review paper. RJMS 2019; 26 (8) :42-55
URL: http://rjms.iums.ac.ir/article-1-5591-fa.html
URL: http://rjms.iums.ac.ir/article-1-5591-fa.html
صحرایی سیده سعیده، کلهر ناصر، شیخ حسن محسن. کاربرد داربست‌ها در مهندسی بافت غضروف. مجله علوم پزشکی رازی. 1398; 26 (8) :42-55
دانشجوی دکتری زیست فناوری پزشکی، گروه سلول بنیادی مزانشیمی، جهاد دانشگاهی قم، قم، ایران ، m.sheykhhasan@acecr.ac.ir
چکیده: (5471 مشاهده)
بافت غضروف به دلیل ماهیت خود که فاقد عروق خونی و اعصاب است، با یک چالش بالینی جهت ترمیم و بازسازی غضروف آسیب دیده روبرو میباشد. آسیب به غضروف و بافتهای استئوکندرال میتواند به علت استئوآرتریت، ورزش، سرطانهای تهاجمی، استرسهای تکراری و التهاب بافت باشد که با توجه به ظرفیت محدود آن برای بازسازی و یا ترمیم، نیاز به سیستمهای مناسب جایگزین است که بتواند عملکرد طبیعی بافت را از لحاظ فیزیکی، مکانیکی، بافت شناسی و بیولوژیکی دارا باشد. یکی از مهم ترین روش های جایگزین که به عنوان راه حلی کارا در این زمینه معرفی شده است، استراتژی مهندسی بافت میباشد. هدف اصلی مهندسی بافت و پزشکی بازساختی در حوزه ارتوپدی، توسعه جایگزینهای زیستی به منظور بازسازی، حفظ و یا بهبود بافت آسیب دیده و عملکرد اندام غضروفی میباشد. عناصر اصلی در استراتژی مهندسی بافت متشکل از سلولهای ترمیم کننده، فاکتورهای رشد، سیتوکینها و داربستهای مناسب می باشند. مواد زیستی مورد استفاده در مهندسی بافت به عنوان داربست به دو دسته کلی طبیعی و مصنوعی تقسیم بندی میشوند. یک داربست ایده آل، باید دارای خواص زیست سازگاری و مکانیکی مطلوب همراه با زیست تخریب پذیری مناسب بوده و بتواند همراه با تعاملات موثر بین سلولی، فرآیند غضروف سازی را نیز القا نماید. در دهههای اخیر، از فناوری نانو نیز به عنوان یک ابزار قدرتمند جهت کمک به مهندسی بافت غضروفی استفاده شده است. علم نانومواد روشهای جدیدی برای بهبود و تقویت مهندسی بافت ارائه کرده است. هدف از این مقاله ارائه یک مروری دقیق از بازسازی و ترمیم بافت غضروف با استفاده از استراتژی های مهندسی بافت میباشدو ارزشیابی یادگیری دانشجویان پرستاری و همچنین در زمان پذیرش مسئولیت‌های حرفه‌ای افراد در علوم پزشکی استفاده شود.
نوع مطالعه: مروري |
موضوع مقاله:
بیولوژی (زیست شناسی)
فهرست منابع
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