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جلد 26، شماره 3 - ( 3-1398 )                   جلد 26 شماره 3 صفحات 40-50 | برگشت به فهرست نسخه ها

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Dehghan Z, Ayat H. Animal toxins and their analgesic properties. RJMS. 2019; 26 (3) :40-50
URL: http://rjms.iums.ac.ir/article-1-5233-fa.html
دهقان زینب، آیت هدا. توکسینهای حیوانات و خاصیت ضددردی آنها. مجله علوم پزشکی رازی. 1398; 26 (3) :40-50

URL: http://rjms.iums.ac.ir/article-1-5233-fa.html


دانشگاه شهرکرد، شهرکرد، ایران ، ayat-h@sci.sku.ac.ir
چکیده:   (303 مشاهده)
احساس درد مسئله اصلی بسیاری از بیماری‌ها است که از لحاظ اجتماعی، روانی و جسمی اثرات مخرب بر افراد دارد. اثر ناقص و عوارض جانبی داروهای ضد درد، نیاز به بررسی ترکیبات جدید تسکین‌دهنده را ایجاد کرده است. کانال‌های یونی، رسپتورهای استیل کولین و گاما آمینوبوتریک اسید و مولکول‌هایی همچون نیتریک اکساید در مسیرهای درد درگیر هستند. مطالعات متعدد بر سموم حیوانات و حشرات نشان داده است که بسیاری از این سموم حاوی مولکول‌های کوچک با خواص درمانی و اثرات ضد درد هستند. پپتیدهای مسکن کارآمدی از زهر عقرب، مار، عنکبوت و حلزون دریایی جدا شده‌اند که اثر مهارکننده بر کانال‌ها و مولکول‌های درگیر در درد نشان داده‌اند. این مقاله مروری بر توکسین‌های کاربردی زهر حیوانات در تسکین درد دارد.
واژه‌های کلیدی: زهر، ضد درد، توکسین، کانال های یونی.
متن کامل [PDF 1776 kb]   (32 دریافت)    
نوع مطالعه: مروري | موضوع مقاله: داروسازی

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