Volume 24, Issue 160 (10-2017)                   RJMS 2017, 24(160): 7-16 | Back to browse issues page

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Bashiri J, NourAzar A, Purrazi H. Effect of three months aerobic training on Wnt-signaling pathway in skeletal muscle of male rats. RJMS. 2017; 24 (160) :7-16
URL: http://rjms.iums.ac.ir/article-1-4566-en.html
PhD, Associate Professor of Exercise Physiology Tabriz Branch, Islamic Azad University, Tabriz, Iran
Abstract:   (962 Views)
Background: Atrophy in skeletal muscle plays an important role in disease-related tissue dysfunction such as sarcopenia. The Wnt-signaling pathway has been shown to be critical for skeletal muscle development. Current evidence suggests that exercise trainings may alter hypertrophy-related signaling in skeletal muscle. Therefore, the purpose of this study was investigating the effect of three months aerobic training on Wnt-signaling pathway in skeletal muscle of male rats.
Methods: This study was conducted as a two-group experimental design and sixteen 3-month-old male rats were selected and randomly divided into two groups of aerobic training (n=8) and control (n=8). Rats in trained group participated in the aerobic training program for three months (75-80% AWT IMAGE). 48 hours after the last training session, the soleus muscle of rats were extracted and β-catenin and glycogen synthase kinase-3β mRNA evaluated by Real Time-PCR. Independent t-test was applied for statistical analysis of the data (P<0.05).
Results: β-catenin gene expression of trained group (1.11±0.17) was no-significantly lower than the control group (1.60±0.99) (30%, P=0.154). However, glycogen synthase kinase-3β gene expression of trained group (10.36±3.51) was significantly higher than the control group (1.99±1.2) (420%, P=0.001).
Conclusion: In general, it seems that a three months aerobic training was effective in increasing glycogen synthase kinase-3β gene expression in skeletal muscle. This may be associated with an increased risk of muscle atrophy. However, more researches are needed to identify effects of different exercise trainings on Wnt-signaling pathway.
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Type of Study: Research | Subject: Exercise Physiology

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