Volume 24, Issue 164 (2-2018)                   RJMS 2018, 24(164): 43-51 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

moradi S, Khorrami L, Maghbooli Z, Mirzaei K. The relationship between gene variants TGF-β1 (rs :1800470) with anthropometric and bone mineral density characteristics in postmenopausal women referred to Shariati Hospital in Tehran. RJMS. 2018; 24 (164) :43-51
URL: http://rjms.iums.ac.ir/article-1-4519-en.html
PhD, Department of Community Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (646 Views)

Background: Currently, genetics is considered to be a major factor in the risk of osteoporosis and obesity.Therefore, we investigated possible association between TGFβ1 polymorphisms (rs: 1800470) with anthropometric and bone mineral density characteristics in postmenopausal women referred to Shariati Hospital in Tehran.
Methods: In this study, 254 postmenopausal women aged 46 to 78 years were examined. Body composition measured by Body Composition Analyzer. Physical activity using the short form of physical activity questionnaire (IPAQ) was performed. Bone mineral density was measured by DEXA method. DNA samples from participants were genotyped using RFLP-PCR method. The results were analyzed by SPSS software version 20 and ANOVA method.
Results: Our results showed that prevalence of osteoporosis in lumber and hip Tehranian women were 17.7% and 2.4% respectively. For first time in Iran, we found that genotype frequencies for TGFβ1 polymorphism (rs1800470) were: TT: 28.3%, TC: 48%, CC: 23.6% respectively. TGFβ1 polymorphism (rs1800470) in Iranian postmenopausal women after adjustment for age, age of menopause weight, physical activity, calorie intake were not associated with demography, body composition and bone bharacteristics (p>0.05).
Conclusion: It seems that TGF-β1 variants (rs: 1800470) in postmenopausal Iranian women did not have direct association with bone mineral density and body composition.
 
 

Full-Text [PDF 909 kb]   (94 Downloads)    
Type of Study: Research | Subject: Genetic

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2018 All Rights Reserved | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb